A surrogate model is a black box model that reproduces the output of another more complex model at a single time point. This is to be distinguished from the method of surrogate data, used in time series. The purpose of a surrogate is to reduce the time necessary for a computation at the cost of rigor and generality. We describe a method of constructing surrogates in the form of support vector m...

Background: Surrogate outcomes are often utilized when disease outcomes are difficult to directly measure. When a biological threshold effect exists, surrogate outcomes may only represent disease in specific subpopulations. We refer to these outcomes as “partial surrogate outcomes.” We hypothesized that risk models of partial surrogate outcomes would perform poorly if they fail to account for t...

BACKGROUND: Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins). METHODS AND RESULTS: We examine two sep...

The temporal autocorrelation (AC) function associated with monitoring order parameters characterizing conformational fluctuations of an enzyme is analyzed using a collection of surrogate models. The surrogates considered are phenomenological stochastic differential equation (SDE) models. It is demonstrated how an ensemble of such surrogate models, each surrogate being calibrated from a single t...

A novel ‘Delay Vector Variance’ (DVV) method for detecting the presence of determinism and nonlinearity in a time series is introduced. The method is based upon the examination of local predictability of a signal. Additionally, it spans the complete range of local linear models due to the standardisation to the distribution of pairwise distances between delay vectors. This provides consistent a...

The increasing use of expensive computer simulations in engineering places a serious computational burden on associated optimization problems. Surrogate-based optimization becomes standard practice in analyzing such expensive black-box problems. This article discusses several approaches that use surrogate models for optimization and highlights one sequential design approach in particular, namel...

The temporal autocorrelation (AC) function associated with monitoring order parameters characterizing conformational fluctuations of an enzyme is analyzed using a collection of surrogate models. The surrogates considered are phenomenological stochastic differential equation (SDE) models. It is demonstrated how an ensemble of such surrogate models, each surrogate being calibrated from a single t...

a bstract   background: there are a few studies about commissioning mothers’ understanding from the surrogacy during 9 months of waiting for delivery in iran and other countries. this study was conducted with an aim to explore and explain the nature of concerns (experiences) of commissioning mothers. materials and methods:  a qualitative design with a conventional content analysis approach was ...