Abstract Objective: The aim of current study was evaluation of group-based diabetes self-management education (group-based DSME) effectiveness in improving glycemic control among type 2 diabetic patients attending the Yazd Diabetes Research Center in 2014. Materials and Methods: The study design was quasi-experimental with control group.In this study, 62 diabetic patients were randomly a...

Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors will reduce the risk of long-term complications and drug side effects. Streptozotocin well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes in animals. It also interferes cellular oxidative mechanisms. Ph...

ETHNOPHARMACOLOGICAL RELEVANCE The Juglans regia L. leaf has been traditionally used for treatment of diabetes mellitus in Iran. But yet, no controlled human study has determined its efficacy in diabetic patients. The present study was designed to investigate the effects of the Juglans regia leaf extract on hyperglycemia and lipid profiles in type II diabetic patients. MATERIALS AND METHOD To...

We analyzed the changes of glycemic control over 12 months and the factors influencing blood glucose in 162 Japanese patients with type 2 diabetes having inadequate glycemic control despite sulfonylurea-based therapy who received add-on sitagliptin. Hemoglobin A1c (HbA1c) decreased significantly after 4 weeks of treatment, and this improvement was maintained for 1 year, although HbA1c was sligh...

background: diabetes mellitus is a serious public health problem worldwide and particularly in developing countries. in algeria, this metabolic disorder occurs with a wide variety or atypical forms that linked to multiple risk factors including local habits and traditions. this study aimed to determine the impact of risk factors (metabolic syndrome, social, cultural, physical activity, family h...

In traditional practice medicine, plants are used in many countries to control diabetes mellitus. The hypoglycaemic actions of these medicinal plants are beings studied. Fenugreek (Trigonella foenum graecum) has been documented as a traditional treatment of diabetes. In the present study, oral administration of alcoholic fenugreek extract (0.1, 0.25, 0.5 g/kg body wt.) and glibenclamide (600 mg...

BACKGROUND Fewer circulating endothelial progenitor cells (EPCs) and increased plasma (C-term) stromal cell-derived factor 1α (SDF-1α), a substrate of DPP-4, are biomarkers, and perhaps mediators, of cardiovascular risk and mortality. Short-term/acute treatment with DPP-4 inhibitors improve EPC bioavailability; however, long-term effects of DPP-4i on EPCs bioavailability/plasma (C-term) SDF-1α ...

The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity and therefore the strain is used as a pharmacological model for type 2 diabetes. The aim of the current study was to compare the pharmacokinetics an...