OBJECTIVES The goal of this study was to determine the bioactivity of urocortin (Ucn) in experimental heart failure (HF). BACKGROUND Urocortin may participate in cardiovascular function and pressure/volume homeostasis. Its effects in HF are unknown. METHODS Eight normal sheep and eight sheep with pacing-induced HF received ovine Ucn (10, 50, and 100 mg intravenous boluses at 2-h intervals) ...

Purpose: To define the maximum tolerated dose and the dose-limiting toxicity of the kinase modulator UCN-01 administered as a short (1-3 hours) infusion to patients with refractory solid tumors and to evaluate the pharmacokinetics of this novel agent. Experimental Design: Twenty-four patients (15 men, 9 women; median age, 59 years; Eastern Cooperative Oncology Group Performance Status, 0-2) wer...

Background: Critical value and urgent sample result notification is widely accepted in the diagnostic fraternity as an important factor, it may affect patient care safety. Timely release of these test per individual laboratory protocol becomes internal part quality reporting system. The present study was aimed at evaluating effective implementation existing clinical (UCN) biochemistry tertiary ...

Cyprus is a divided country affected by long-term conflict between Greek-Cypriots and Turkish-Cypriots, but meeting among key politicians in Switzerland 2017 raised hopes that the 43-year division would come to an end. Ahead of this meeting, peace protests organised Unite Now (UCN) erupted Nicosia urging find solution. This study explores how UCN protest signage was used during demonstrations p...

Finite-element methods along with Monte Carlo simulations were used to design a magnetic storage device for ultracold neutrons (UCN) to measure their lifetime. A setup was determined which should make it possible to confine UCN with negligible losses and detect the protons emerging from β-decay with high efficiency: stacked superconducting solenoids create the magnetic storage field, an electro...

Eduardo P. Pérez E. Marine Biologist, Universidad Católica del Norte (UCN), Chile. M.Sc. and Ph.D., Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), Mexico. Professor, Department of Marine Biology, UCN, Chile and Researcher, Centro de Estudios Avanzados en Zonas Áridas, Coquimbo, Chile. Address: Casilla 117, Coquimbo, Chile, e-mail: [email protected] Omar Defeo. Ph.D., CINVESTAV-IPN, M...

Checkpoint kinase 1 (Chk1) is an evolutionarily conserved serine/threonine kinase that plays an important role in G2/M checkpoint signaling. Here, we evaluate the radiosensitizing effects of a novel selective Chk1 inhibitor MK-8776, comparing its efficacy with a first-generation Chk1 inhibitor UCN-01, and attempt to elucidate the mechanism of radiosensitization. In a clonogenic survival assay, ...

Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging agents. Isogranulatimide is a G(2) checkpoint inhibitor containing a unique indole/maleimide/imidazole skeleton identified in a phenotypic cell-based screen; however, the mechanism of action of isogranulatimide is unknown. Using natural and synthetic isogranulatimide a...