The Visual Concept Detection Task (VCDT) of ImageCLEF 2008 is described. A database of 2,827 images were manually annotated with 17 concepts. Of these, 1,827 were used for training and 1,000 for testing the automated assignment of categories. In total 11 groups participated and submitted 53 runs. The runs were evaluated using ROC curves, from which the Area Under the Curve (AUC) and Equal Error...

Background Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature is necessary for prognosis of OTSCC. Methods Five microarray data sets of OTSCC from the Gene Expression Omnibus (GEO) and one data set from The Cancer Genome Atlas (TCGA) were obtained. Differentially expressed genes (DEGs) of GEO data sets were identified by integrat...

The black hole singularity plays a crucial role in formulating Hawking's information paradox. global spacetime analysis may be reconciled with unitarity by imposing final state boundary condition on the spacelike singularity. Motivated proposal, we explore effect of projection two dimensional conformal field theories. We calculate time evolution under postselection employing real part pseudoent...

The accuracy of a diagnostic test with continuous-scale results is of high importance in clinical medicine. It is often summarised by the area under the ROC curve (AUC). In this article, we discuss and compare nine non-parametric confidence intervals of the AUC for a continuous-scale diagnostic test. Simulation studies are conducted to evaluate the relative performance of the confidence interva...

The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [...

BACKGROUND Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study was performed to examine the placebo response in SIT trials that employed a ba...

PURPOSE Investigate the role of metabolites in bioequivalence (BE) assessment. METHODS. Sets of ordinary differential equations are used to generate concentration - time data for both parent drug (P) and metabolite (M). The calculations include 24 subjects, two different formulations (Test, Reference), and a range of Test/Reference ratios for the fraction of dose absorbed and the rate of absorp...

Omland and colleagues’ paper examining the outcome of IVF in a ‘natural cycle’ model to study aetiological differences between endometriosis and other infertility groups interested us (Omland et al., 2001). Their findings differ from ours and we have tried to understand these differences. It is important to distinguish between this study, which used HCG as a surrogate for the endogenous LH surg...

BACKGROUND The intranasal (IN) administration of epinephrine could be an alternative route for anaphylaxis treatment. Although IN epinephrine absorption has been demonstrated in animals, such data in humans are still lacking. OBJECTIVE To study the pharmacokinetics of IN epinephrine absorption in humans. METHODS Each healthy adult (n = 5) was administered IN saline, IN epinephrine at variou...

Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cort...