The cytosolic antiviral innate immune sensor RIG-I distinguishes 5' tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain. Recently discovered mutations in ATPase motifs can lead to the multi-system disorder Singleton-Merten Syndrome (SMS) and increased interferon levels,...

As motion capture techniques become more advanced and accessible, motion capture data has become an increasingly popular source of efficient, realistic animation. The process of motion capture involves placing markers on an actor’s body and recording movement data for each marker. This data can then be mapped onto a digital human skeleton, called a rig, which consists of joints (e.g. hips, elbo...

Some of the most convincing film and video effects are created in digital post-production by removing apparatus that supports or manipulates actors and objects. Wires, cranes and other objects can be removed by digitally painting them out of the scene provided some ‘clean plate’ image is available for pasting in the missing regions. This paper addresses the problem when no such plate is availab...

These studies seek to determine whether the locomotory behavior of the extending tip of growing nerve fibers exhibits chemotaxis to nerve growth factor (NGF). Sensory neurons from dissociated dorsal root gangha of chick embryos were cultured within semisolid agar matrices containing concentration gradients of NGF which diffused from an adjacent source. A preferential orientation of approximatel...

This paper presents the design and testing of a system for autonomous tracking, pickup, and delivery of cargo via an unmanned helicopter. The tracking system uses a visual servoing algorithm and is tested using open loop velocity control of a six degree of freedom gantry system with a camera mounted via a pan-tilt unit on the end effecter. The pickup system uses vision to direct the camera pan ...

Emerging evidence indicates that ionizing radiation (IR) and chemotherapy activate Type I interferon (IFN) signaling in tumor and host cells. However, the mechanism of induction is poorly understood. We identified a novel radioprotective role for the DEXH box RNA helicase LGP2 (DHX58) through its suppression of IR-induced cytotoxic IFN-beta [1]. LGP2 inhibits activation of the RIG-I-like recept...

Viral RNA represents a pattern molecule that can be recognized by RNA sensors in innate immunity. Humans and mice possess cytoplasmic DNA/RNA sensors for detecting viral replication. There are a number of DEAD (Asp-Glu-Ala-Asp; DExD/H) box-type helicases in mammals, among which retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA50) are indispensable for...

This paper presents experimental activities that have been performed in the Automotive Engineering Centre laboratories in Universiti Malaysia Pahang for developing a test-rig based on a modern motorcycle engine. The experimental engine test-rig was developed based on an eddy current dynamometer which was coupled to a four-stroke singlecylinder SI motorcycle engine. Moreover, the test-rig consis...

This paper describes experiences gained during the design, implementation and use of the CMU Accent Network Operating System, its. predecessor, the University of Rochester RIG system and its successor CMU’s Mach multiprocessor operating system. It outlines the major design decisions on which the Accent kernel was based, how those decisions evolved from the RIG experiences and how?hey had to be ...