Habitual snoring in adults may be related to upper airway dysfunction, although the precise relationship has never been studied. We quantitatively measured snoring and correlated it with upper airway properties in 50 apneic and 59 nonapneic adult male patients. Both groups were similar in terms of nasal airflow resistance and pulmonary function tests. We found a significant correlation between ...

Obstructive sleep apnea syndrome has been recognized as a major public health problem. Both its cardiovascular and metabolic comorbidities and symptoms motivate for an accurate diagnosis and appropriate treatment. The main stimulus associated with obstructive sleep apnea (OSA) and explaining deleterious consequences is intermittent hypoxia. The upper airway resistance syndrome (UARS) has been d...

Objective. To review outcome measures and objective adherence data for patients treated with hypoglossal nerve stimulation (HNS) therapy for moderate to severe obstructive sleep apnea (OSA). Study Design. Case series with chart review. Setting. Academic sleep medicine center. Subjects and Methods. The first 20 implanted patients to complete postoperative sleep laboratory testing were assessed. ...

We hypothesized that upper airway collapsibility is modulated dynamically throughout the respiratory cycle in sleeping humans by alterations in respiratory phase and/or airflow regimen. To test this hypothesis, critical pressures were derived from upper airway pressure-flow relationships in six tracheostomized patients with obstructive sleep apnea. Pressure-flow relationships were generated by ...

The upper airway (UA) of adult animals is known to contain carbon dioxide-sensitive receptors and UA CO2 reflexly affects breathing, UA dilator muscle activity and UA resistance. These effects may function in the control of UA patency. There is evidence that some UA reflexes are stronger in young than in adult animals, but it is not known whether CO2-sensitive receptors are present in the UA of...

Poiseuille’s law is central to the understanding and management of all airway obstructions in children, with the clinical impact of even a small reduction in radius being compounded by the inverse relationship of the resistance to the radius to the power 4. Indeed deterioration from a ‘mild’ obstruction to life threatening airway compromise may be heralded by slight decrease in airway diameter ...

A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Assessment of upper airway dynamics in awake sleep apnea patients wi...

RESPIRATORY-RELATED ACTIVATION OF THE UPPERAIRWAY-DILATING AND TONGUE-PROTRUDING MUSCLES IS WIDELY KNOWN to be effective in reducing the tendency of the upper airway and tongue to collapse during sleep. The electromyographic (EMG) activity of the genioglossus (GG) muscle increases in the head-up and/or supine position and thereby acts to maintain upper airway patency.1-4 However, sleeprelated r...

1. Willms D, Shure D: Pulmonary edema due to upper airway obstruction in adults. Chest 1988; 94:1090-2 2. Dohi S, Okubo N, Kondo Y: Pulmonary edema after airway obstruction due to bilateral vocal cord paralysis. Can J Anaesth 1991; 38:492-5 3. Brandom BW: Pulmonary edema after airway obstruction. Int Anesthesiol Clin 1997; 35:7584 4. Deepika K, Kenaan CA, Barrocas AM, Fonseca JJ, Bikazi GB: Neg...

We have shown that a polynomial equation, FP = AP3 + BP2 + CP + D, where F is flow and P is pressure, can accurately determine the presence of inspiratory flow limitation (IFL). This equation requires the invasive measurement of supraglottic pressure. We hypothesized that a modification of the equation that substitutes time for pressure would be accurate for the detection of IFL and allow for t...