Mash-ups extract data fragments from disparate sources, and combine and transform the extracted fragments for display. Currently, mash-up developers tend to employ ad hoc representations for mash-up data, view mash-ups as applications, and use imperative scripts to extract and transform data fragments. These approaches can make mash-up development hard, and the mash-ups’ run-time performance po...

The ubiquitin-proteasome system (UPS) is responsible for turnover of most cellular proteins in eukaryotes. Protein degradation by the UPS serves quality control and regulatory functions. Proteasome inhibition showed great promise in effectively treating cancer and restenosis. UPS dysfunction in cardiac hypertrophy and failure has recently been suspected but remains to be investigated. A system ...

The ubiquitin proteasome system (UPS) degrades abnormal proteins and most unneeded normal proteins, thereby playing a critical role in protein homeostasis in the cell. Proteasome inhibition is effective in treating certain forms of cancer, while UPS dysfunction is increasingly implicated in the pathogenesis of many severe and yet common diseases. It has been previously shown that doxorubicin (D...

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system (UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective proteolytic system in which substrates are recognized and tagged with ubiquitin for processive degradation by the proteasome. Autophagy is a bulk degradative system that uses lysosomal hydrolases to degrade proteins as we...

We investigated the Ubiquitin-Proteasome System (UPS), major nonlysosomal intracellular protein degradation system, in the genesis of experimental postsurgical peritoneal adhesions. We assayed the levels of UPS within the adhered tissue along with the development of peritoneal adhesions and used the specific UPS inhibitor bortezomib in order to assess the effect of the UPS blockade on the perit...

The process of consolidating usability problems (UPs) is an integral part of usability evaluation involving multiple users/analysts. However, little is known about the mechanism of this process and its effects on evaluation outcomes, which presumably influence how developers redesign the system of interest. We conducted an exploratory research study with ten novice evaluators to examine how the...

This paper studies two types of threshold-induced effects: a surge of new sign-ups around the time when the thresholds of group-buying deals are reached, and a stronger positive relation between the number of new sign-ups and the cumulative number of sign-ups before the thresholds are reached than afterwards. This empirical study uses a dataset that records the inter-temporal cumulative number ...

This paper describes the architecture and implementation of a DC-Uninterruptible Power Source (DC-UPS) designed as an internal component for IBM AS/400 processor and I/O towers. This DC-UPS supports a processor or I/O tower requiring a maximum of 3100 watts of input ac line power. Unlike the large majority of AC-Uninterruptible Power Sources (AC-UPSs) found in the marketplace, which supply 50–6...

This study explored carryover effects from show-ups to subsequent line-up identifications using a novel paradigm in which participants rendered multiple identification judgements. A total of 160 participants studied a series of faces and subsequently viewed a series of target-absent and target-present show-ups. Following a retention interval, participants then made identification judgements fro...

The distortion obtained in the Uninterruptible Power Supply (UPS) output due to increasing use of rectifiers in critical loads an effective strategy is needed to control the output of UPS system. Sinusoidal pulse width modulation (SPWM) and space vector pulse width modulation (SVPWM) are the most popular PWM techniques for three phase UPS system. As compared to SPWM, SVPWM is much effective in ...