BACKGROUND: The prevalence of diabetes is steadily increasing worldwide particularly in developing countries, it is associated with chronic complications which lead to considerable mortality and morbidity. Type II diabetes is considered as a disease of innate immune response, sialic acid represent as a marker of acute phase protein is found to be elevated in diabetic subjects. MATERIALS AND MET...

Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early diagnosis of acute renal failure. Urinary retinol binding protein, myoglobin, an...

Sir, Recently, our group conducted a supplementary study on urinary abnormalities following karate (kumite) competitions in professional female athletes. In a previous issue of NDT Plus [1], our group presented data showing significantly increased proteinuria of a mixed type (albumin and beta2-microglobulin or B2M) with prominence of albumin, as a glomerular urine protein, in 18 professional (1...

Sir, Recently, our group conducted a supplementary study on urinary abnormalities following karate (kumite) competitions in professional female athletes. In a previous issue of NDT Plus [1], our group presented data showing significantly increased proteinuria of a mixed type (albumin and beta2-microglobulin or B2M) with prominence of albumin, as a glomerular urine protein, in 18 professional (1...

Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication of liver transplantation. For early detection of AKI, various urinary biomarkers such as monocyte chemotactic protein-1, liver-type fatty acid-binding protein, interleukin-18, osteopontin, cystatin C, clusterin and neutrophil gelatinase-associate...

PURPOSE We investigated the role of Tamm-Horsfall protein in interstitial cystitis. MATERIALS AND METHODS Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein. RESULTS Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statis...

A suitable and standardized protein purification technique is essential to maintain consistency and to allow data comparison between proteomic studies for urine biomarker discovery. Ultimately, efforts should be made to standardize urine preparation protocols. The aim of this study was to develop an optimal analytical protocol to achieve maximal protein yield and to ensure that this method was ...

Amyloidosis of urinary bladder is a rare condition and may be primary or secondary in nature. A case of primary localized vesical amyloidosis (VA) in a 40-yr-old man is described confused with neoplasm by cystoscopic, urographic. Surgical specimens obtained by transurethral resection (TUR) were diagnostic and histologically revealed amyloid deposits in sub-epithelial stroma with chronic inflamm...

Feline lower urinary tract disease is an important clinical problem in cats. Epidemiological data based on urinary stones submitted for examination show over the last decade a consistent trend for struvite calculi to decrease and calcium oxalate to increase (1,2). The risk for cats to develop urolithiasis is related to dietary and nondietary factors. Higher solute concentrations, a subsequent s...

Urine has evolved as one of the most important biofluids in clinical proteomics due to its noninvasive sampling and its stability. Yet, it is used in clinical diagnostics of several disorders by detecting changes in its components including urinary protein/polypeptide profile. Despite the fact that majority of proteins detected in urine are primarily originated from the urogenital (UG) tract, d...