نتایج جستجو برای: using strontium stable isotope analysis therefore
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In higher eukaryotes many genes encode protein isoforms whose properties and biological roles are often poorly characterized. Here we describe systematic approaches for detection of either distinct isoforms, or separate pools of the same isoform, with differential biological properties. Using information from ion intensities we have estimated protein abundance levels and using rates of change i...
In higher eukaryotes many genes encode protein isoforms whose properties and biological roles are often poorly characterized. Here we describe systematic approaches for detection of either distinct isoforms, or separate pools of the same isoform, with differential biological properties. Using information from ion intensities we have estimated protein abundance levels and using rates of change i...
Dynamics of lead metabolism were studied by replacement of a portion of the dietary lead with stable isotope tracers, and maintaining subjects on controlled diets for about 6 months. Results for one subject have been previously reported. Preliminary data are now available for a second subject. Although the data on the two subjects are basically similar, there are also significant differences. T...
Leprosy is one of the most notorious diseases in history, widely associated with social stigma and exclusion. This study builds on previous work to reevaluate medicohistorical evidence for relation leprosy. achieved by isotopic palaeopathological analyses adolescent skeletons (10–25 years old) from Anglo-Scandinavian (10th–11th centuries AD) parish cemetery St. John at Castle Gate Norwich (East...
Quantification of stable isotope tracers has revealed the dynamic state of living tissues. A new form of imaging mass spectrometry quantifies isotope ratios in domains much smaller than a cubic micron, enabling measurement of cell turnover and metabolism with stable isotope tracers at the single-cell level with a methodology we refer to as multi-isotope imaging mass spectrometry. In a first-in-...
Ontogenetic diet shift in the euphausiid Euphausia pacifica quantified using stable isotope analysis
Empires have transformed political, social, and environmental landscapes in the past and present. Although much research on archaeological empires focuses on large-scale imperial processes, we use biogeochemistry and bioarchaeology to investigate how imperialism may have reshaped regional political organization and regional migration patterns in the Wari Empire of the Andean Middle Horizon (ca....
Stable isotope dilution mass spectrometry (MS) represents the gold standard for quantification of endogenously formed cellular metabolites. Although coenzyme A (CoA) and acyl-CoA thioester derivatives are central players in numerous metabolic pathways, the lack of a commercially available isotopically labeled CoA limits the development of rigorous MS-based methods. In this study, we adapted sta...
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