Senecionine (SEN) is a representative of the hepatotoxic pyrrolizidine alkaloids. Although phase I metabolism for cytochrome P450-mediated metabolic activation of SEN was investigated extensively, phase II metabolism for glucuronidation of this compound has not been investigated until now. In our present study, one unique glucuronidation product of SEN in human liver microsomes (HLMs) was ident...

INTRODUCTION Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS Using Western blot we studied 1 SEN and 3 SEGA samples; SEN and 1 SEGA came from the same TS patient. We eva...

Simple heteroscedasticity is discussed in detail by Sen (1984), Sen & Ponnuswamy (1991) and Rahaman and Sen (1995). In this paper, heteroscedasticity is considered in a RBD assuming error variances vary from cell to cell. There are more than one observations per cell in this layout. The twoway general heteroscedastic model is considered here with interaction. On the assumption that the unequal ...

The flesh-eating bacterium group A Streptococcus (GAS) binds and activates human plasminogen, promoting invasive disease. Streptococcal surface enolase (SEN), a glycolytic pathway enzyme, is an identified plasminogen receptor of GAS. Here we used mass spectrometry (MS) to confirm that GAS SEN is octameric, thereby validating in silico modeling based on the crystal structure of Streptococcus pne...

Amartya Sen has correctly sought to correct some shortcomings within neoclassical economic theory. Nonetheless, there still exists a tension in his work. His overall frame of analysis is still congruent with much of the neoclassical tradition. However, his critiques seem to imply that a sharp break with neoclassical theory is necessary. This conflict is examined in light of the connections betw...

Suppes-Sen Dominance is a commonly accepted criterion of impartiality in distributive justice. Mariotti (1999) characterized the Nash bargaining solution using Nash (1950)’s Scale Invariance (SI) axiom and an axiom named Suppes-Sen Proofness (SSP) that embodies the Suppes-Sen principle. By adding a relative equity component to SSP, we …rst consider a stronger version of of it, the Strong Suppes...