abstract carcinoma of the cervix is a common neoplasm and accounts for a considerable number of cervical diseases that lead to death in developing countries. in these countries early detection and improved methods of treatment have resulted in comparatively better control of the cancer and long survival however, invasive and metastatic disease still occurs. the authors present the case report o...

BACKGROUND Human uterine natural killer (uNK) cells, the dominant lymphocytes in early pregnancy decidua, are important for spiral arterial remodelling. uNK cells are thought to arise from circulating CD56(bright) NK cells that egress into decidualizing endometrium. Both incomplete spiral arterial modification and aberrant NK cell function have been linked with pre-eclampsia, a syndrome that is...

Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 produced by trophoblast cells and regulates the function of natural killer (NK) at maternal-fetal interface via to Tim-3 (T-cell Ig mucin domain-containing protein 3) molecules. Natural lymphocytes belong innate lymphoid cells, which have cytotoxic effect on target are capable prod...

The literature suggests that effective defence against tumour cells requires contributions from both Natural Killer (NK) and CD8+ T cells. NK are spontaneously active infected target cells, whereas take some times to activate cell called as cell-specific targeting, kill the virus. interaction between has produced other cell, tumour-specific We illustrate tumour–immune through mathematical model...

NK cell development is far less understood compared with that of T and B cells despite the critical importance of NK cells in innate immunity. Mice lacking the transcription factor IFN regulatory factor-2 (IRF-2) are known to exhibit NK cell deficiency. However, the role of IRF-2 in NK cell development has remained unclear. In this study we found that NK cell deficiency in the periphery in IRF-...

Abstract Acute Lymphoblastic Leukemia (ALL) represents the most common pediatric cancer. Significant improvements in chemotherapy regimens caused a leap 5-year survival rates to surpass 90%. However, relapse significantly lowers chances of less than 50% some cases due resistance developed by malignant cells chemotherapy. Natural Killer (NK) are promising immunotherapy alternative for their abil...

Because NK cells secrete cytotoxic granules and cytokines that can destroy surrounding cells and help shape the subsequent immune response, they must be kept under tight control. Several mechanisms, at different levels, are in place to control NK cell function. In this study, we describe a novel mechanism regulating NK cell function in which NK cells acquire ligands for activating receptors fro...