Background: Marginal ulceration (MU) is a recognized complication of Roux-en-Y gastric bypass (RYGB) surgery. While several possible risk factors have been reported, the mechanism of MU remains incompletely understood. The aim of this study was to compare the effect of surgical technique on the incidence of MU. Methods and Material: This was a retrospective study of 749 patients undergoing RYGB...

Propofol has been suggested to have in vivo airway relaxant effects, although the mechanism is still unclear. In this study, we determined whether propofol could antagonize methacholine-induced bronchoconstriction and determined whether vagotomy modifies this relaxant effect. Fourteen mongrel dogs anaesthetized with pentobarbital and pancuronium were assigned to a control group (n=7) and a vago...

INTRODUCTION the intestinal Na(+)/glucose cotransporter (SGLT1) displays rapid anticipatory diurnal rhythms in mRNA and protein expression. The vagus nerve has been implicated in the entrainment of some transporters. We aimed to clarify the influence of the vagus nerve on the diurnal entrainment pathway for SGLT1 and examine the role of vagal afferent fibers. METHODS male Sprague-Dawley rats ...

Intrathecally applied nicotine reduces bradykinin-induced plasma extravasation (BK-induced PE) in the rat knee joint. This depression is mediated by the hypothalamo-pituitary-adrenal (HPA) axis and is enhanced by interruption of impulse traffic in afferents of the abdominal vagus nerve. Like intrathecal nicotine, electrical stimulation of unmyelinated cutaneous fibers also depresses BK-induced ...

There have been reports of oesophageal reflux following operations performed for peptic ulcer (Clarke, Penry, and Ward, 1965; Windsor, 1964). Reflux has been noted after partial gastrectomy (Windsor, 1964) and also after vagotomy plus a gastric drainage procedure (Clarke et al, 1965). The operation of vagotomy plus gastric drainage could cause reflux oesophagitis to occur either through direct ...

Methods We calculated gastric HCO3 and H+ secretion, as well as nonparietal and parietal volume secretion, in 15 duodenal ulcer patients who had previously undergone successful proximal gastric vagotomy, 15 unoperated duodenal ulcer patients, and 15 normal control subjects. Basal HCO3secretion was not significantly altered after vagotomy, while basal H+ secretion, parietal volume and nonparieta...

1. The acid secretory responses to insulin of forty-seven duodenal ulcer patients after truncal vagotomy and drainage were classified according to the criteria of Hollander (1946) into positive or negative. 2. The acid response to ranges of small doses of pentagastrin was studied in these two groups. In the group with a positive acid response after insulin the dose-response pattern to pentagast...

Francis, Joseph, Shun-Guang Wei, Robert M. Weiss, and Robert B. Felder. Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol 287: H791–H797, 2004; doi:10.1152/ajpheart.00099.2004.— Within minutes of acute myocardial infarction (MI), proinflammatory cytokines increase in the brain, heart, and plasma. We hypothesized that cardi...

Forty patients after vagotomy (truncal vagotomy 18, selective vagotomy 22) with a drainage procedure were given 200 ml of 50% dextrose by mouth (dumping provocation test), the symptoms induced being noted, and any fall in plasma volume was assessed by serial measurement of the haematocrit. An insulin gastric secretion test was also performed on each patient.TWENTY OF THE PATIENTS HAD DUMPING SY...

The considerable difference of opinion which exists regarding the surgical treatment of duodenal ulcer suggests that the ideal operation has not yet been devised. The advantages of a lower morbidity rate with vagotomy and gastrojejunostomy compared with partial gastrectomy are offset by the higher incidence of recurrent ulceration in the former procedure (Cox and Kerr, 1957; Everson, Hutchings,...