DESCRIPTION Aloxi (palonosetron hydrochloride) is an antiemetic and antinauseant agent. It is a selective serotonin subtype 3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical formula is C19H24N2O.HCl, w...

Prior studies of the viscosity of the subunit proteoglycan obtained by dissociative extraction of bovine nasal septum cartilage suggested that the proteoglycan subunit molecule behaves as a rigid rod in aqueous solution over the range of 0.5 to 4.0 M guanidine hydrochloride. A more direct view of dimension and shape can be obtained from light-scattering and viscosity of bovine nasal cartilage p...

Genital herpes is a chronic infection characterized by periodic reactivation. It can produce symptomatic disease in the host although asymptomatic viral excretion can also occur. It is currently the main cause of genital ulceration and an important public health problem that has substantial clinical, psychological, and economic repercussions. This review analyzes the currently available therape...

The aim of the investigation was research N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It found that studied substance effective on cardiac arrhythmias model caused by aconitine hydrochloride, but does not act models calciume chlorideinduced and reperfusion ventricular fibrillation. compound is less toxic than comparison drug lappaconitine hydrobromide acts in lower doses ar...

The objective of this study was to determine the effect of povidone. hydroxypropyl methylcellulose, hydroxypropyl cellulose, lactose and magnesium stearate on the stability of quinapril hydrochloride. The applied HPLC method was validated by the following parameters: selectivity, precision, linearity and accuracy. Binary 1:4 mixtures of quinapril hydrochloride and selected excipients were stabl...

copper amine oxidases (caos) catalyse the oxidative de-amination of biogenic amines which are ubiquitous compounds essential for cell growth and proliferation. the enzymes are homodimers containing both topaquinone and a cu(ii) ions as cofactors at the active site of each subunit. after extraction and purification of chickpea (cicer arietinum) amine oxidase by chromatoghraphy, km and vmax of th...

Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals were provided. Maximum wavelenghts were: 228 nm for ketotifen hydrogen fumarate, 295 nm for azelastine hydrochloride, 265 nm for dimetindene maleate and 255 nm for promethazine hydrochloride. The limi...