Background Cine CMR is the gold standard for evaluation of left ventricular function with high spatial and temporal resolution of the EKG-gated acquisition. Measurements of dyssynchrony have previously been performed using myocardial tagging to measure relative delays in peak shortening of opposing walls. We aim to utilize non-tagged images to quantify dyssynchrony in clinical patients. This is...

The aortic valve, located between the left ventricle and the aorta, allows for unidirectional blood flow, preventing backflow into the ventricle. Aortic valve leaflets are composed of interstitial cells suspended within an extracellular matrix (ECM) and are lined with an endothelial cell monolayer. The valve withstands a harsh, dynamic environment and is constantly exposed to shear, flexion, te...

Dear Sir, Timing of surgery in chronic mitral valve regurgitation has been a long term matter of debate. Data from European Society of Cardiology suggest that a number close to 36 % of surgical treatment in mitral valve regurgitation is performed too early or too late according to guidelines suggestions (Iung et al., 2003). Bileaflet mitral valve prolapse (Barlow’s disease) as correctly reporte...

Transcatheter aortic valve implantation has been associated with a higher rate of cerebrovascular events (CVEs) compared with medical treatment or surgical aortic valve replacement. This multicenter study evaluated in a large cohort of consecutive patients (n=1061) the timing, predictors, and clinical impact of CVEs after transcatheter aortic valve implantation. The incidence of 30-day CVEs was...

introduction: rheumatic heart disease still remains one of the leading causes of congestive heart failure and death owing to valvular pathologies, in developing countries. valve replacement still remains the treatment of choice in such patients.the aim of this study wasto analyze the postoperative outcome of  double valve replacement (mitral and aortic ) in patients of rheumatic heart disease. ...

infective endocarditis is one of the most severe complications of parenteral drug abuse. the outstanding clinical feature of infective endocarditis in intravenous drug abusers is the high incidence of right-sided valve infection, and the tricuspid valve is involved in 60% to 70% of the cases. we herein report a case of isolated pulmonic valve infective endocarditis with a native pulmonary valve.

the patient was a 19 year-old woman with the diagnosis of resistant hypertension, although she was under treatment of three classes of anti-hypertensive drugs (beta blocker, angiotensin receptor blocker, diuretic) for more than one year. in physical examination there was only a significant difference between the systolic blood pressure of upper and lower extremities (200 vs. 120 mmhg), without ...

Process variation is becoming a primal concern in timing closure of LSI (Large Scale Integrated Circuit) with the progress of process technology scaling. To overcome this problem, SSTA (Statistical Static Timing Analysis) has been intensively studied since it is expected to be one of the most efficient ways for performance estimation. In this paper, we study variation of output transition-time....

Valvetrain flexibility enables the optimization of the engine’s ability to breathe across the operating range, resulting in more efficient operation. The authors have shown the merit of improving volumetric efficiency via valvetrain flexibility to improve fuel efficiency at elevated engine speeds in the previous work. This study focuses on production viable solutions targeting similar volumetri...

Pressure control valve (PCV) is implemented in internal combustion engine to regulate crankcase pressure. In this study, the performance of a diaphragm PCV valve is investigated numerically and experimentally. Firstly, numerical simulation is carried out using commercial code to predict the flow and pressure distribution inside the valve. Furthermore, downstream and upstream pressure of the val...