Purpose: p12 is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. Expression of p12 is reduced and/or lost in tumor tissues. The purpose of this study is to correlate in vivo the expression of p12 in oral cancer tissues by immunohistochemistry with clinical and pathological parameters. Experimental Design: Twenty-five cases of normal oral mucosa and 127 ...

Based on oxygen (O2), pH, calcium (Ca2+), and carbonate (CO 22 3 ) sediment pore-water concentration profiles, we compare the benthic dissolution of autochthonous calcite in oligotrophic Lake Lucerne and eutrophic Lake Sempach. Despite their difference in trophic state, the two lakes have similar benthic O2 regimes because L. Sempach is artificially oxygenated. This peculiarity enabled the stud...

nloaded kground: The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous logic processes, including proliferation, differentiation, and development. Studies also showed that is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether is a prognostic indicator for colon cancer. thods: Levels of KLF4 were measured by immunohistochemic...

Several cleavage products of complement component C3 interact with cellular membrane receptors and are associated with important biological activities . The larger fragment of activated C3 (C3b), which binds covalently to surface membranes or antigen-antibody complexes, is a ligand for complement receptor type I (CRI),' a glycoprotein of ^-200,000 Mr found on erythrocytes, phagocytes, lymphocyt...

Diisopropylsilyl ethers were activated with N-bromosuccinimide, and reacted with a fluorous-tagged alcohol, to yield tethered substrates for ring-closing metathesis reactions.

Bacterial infections and sepsis are major problems in critically ill patients. Timely diagnosis and therapy reduce morbidity and mortality. Many studies have included the investigation of various biomarkers whose elevated concentrations can indicate sepsis; among them, PCT proved to be most useful. PCT is synthesized in the thyroid gland as a prohormone of calcitonin. In healthy individuals the...

Purpose: We developed a novel systemic immune-inflammation index (SII) based on lymphocyte, neutrophil, and platelet counts and explored its prognostic value in hepatocellular carcinoma (HCC). Experimental Design: The SII was developed based on a retrospective study of 133 patients with HCC undergoing resection between 2005 and 2006, and validated in a prospective study of 123 patients enrolled...

Hemoglobinopathies are a group of hereditary hemolytic anemia characterized by qualitative (sickle cell disease) or quantitative (thalassemia) defects in the alpha or beta-globin chain synthesis. Homozygotes or compound heterozygotes for the mutated alpha or beta-globin genes can cause severe anemia at an early age. These pathologies are common in some areas (Mediterranean, Africa, India, and S...

Histologic grading of breast cancer defines morphologic subtypes informative of metastatic potential, although not without considerable interobserver disagreement and clinical heterogeneity particularly among the moderately differentiated grade 2 (G2) tumors. We posited that a gene expression signature capable of discerning tumors of grade 1 (G1) and grade 3 (G3) histology might provide a more ...

Introduction: QT interval represents duration of ventricular electrical systole, i.e., the time required for completion of both ventricular depolarization and repolarization. QT interval duration normally varies between leads on the electrocardiography due to variation of repolarization and re-excitability of different ventricular regions. QT dispersion, defined as the difference between maximu...