introduction: hematopoietic stem cells are always in a quiescence state. since they need retroviral transduction to infect dividing cells, they are resistant to retrovirus transduction. they need to be pre-stimulated by a cytokine cocktail. for proliferation without maturation, we suggest mip-1α as a novel factor. material and methods: retroviral vector produced by pg13/ln c8 cells titter on he...

in this paper, a useful classification of all lie subalgebras of a given lie algebraup to an inner automorphism is presented. this method can be regarded as animportant connection between differential geometry and algebra and has many applications in different fields of mathematics. after main results, we have applied this procedure for classifying the lie subalgebras of some examples of lie al...

objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...

support vector regression (svr) solves regression problems based on the concept of support vector machine (svm). in this paper, a new model of svr with probabilistic constraints is proposed that any of output data and bias are considered the random variables with uniform probability functions. using the new proposed method, the optimal hyperplane regression can be obtained by solving a quadrati...

In this paper, we have dened and studied a generalized form of topological vector spaces called s-topological vector spaces. s-topological vector spaces are dened by using semi-open sets and semi-continuity in the sense of Levine. Along with other results, it is proved that every s-topological vector space is generalized homogeneous space. Every open subspace of an s-topological vector space is...

‎We consider four-dimensional lie groups equipped with‎ ‎left-invariant Lorentzian Einstein metrics‎, ‎and determine the harmonicity properties ‎of vector fields on these spaces‎. ‎In some cases‎, ‎all these vector fields are critical points for the energy functional ‎restricted to vector fields‎. ‎We also classify vector fields defining harmonic maps‎, ‎and calculate explicitly the energy of t...

background: prediction of interaction sites within the membrane protein complexes using the sequence data is of a great importance, because it would find applications in modification of molecules transport through membrane, signaling pathways and drug targets of many diseases. nevertheless, it has gained little attention from the protein structural bioinformatics community. methods: in this stu...

OBJECTIVE Proinflammatory cytokines are involved in the pathogenesis of non-thyroidal illness (NTI), as shown by studies with IL-6-/- and IL-12-/- mice. Interleukin (IL)-6 changes peripheral thyroid hormone metabolism, and IL-12 seems to be involved in the regulation of the central part of the hypothalamic-pituitary-thyroid (HPT) axis during illness. IL-18 is a proinflammatory cytokine which sh...

To evaluate the role of a circulating inhibitor of extrathyroidal conversion of T4 to T3 (IEC) in the causation of low T3 states in patients with various nonthyroidal illnesses (NTI), we measured the in vitro T3 production in the presence of ether extract of plasma. Blood samples were obtained from 22 normal subjects and 140 patients with various NTI; liver cirrhosis (LC) 37, diabetes mellitus ...