Neuroprotection may prevent or forestall the progression of incurable eye diseases, such as retinitis pigmentosa, one of the major causes of adult blindness. Decreased cellular ATP levels may contribute to the pathology of this eye disease and other neurodegenerative diseases. Here we describe small compounds (Kyoto University Substances, KUSs) that were developed to inhibit the ATPase activity...

The molecular mechanisms and cellular targets of sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma (HCC), remain to be fully characterized. Recent studies have shown that sorafenib induces tumor cell death through the activation of endoplasmic reticulum stress signaling and/or autophagy in various cellular models. Using liver cancer-derived cell lines, we spe...

In this paper, a heterogeneous intersection formula, method of fusion coordinates, and an error allocation are introduced in order to improve the target coordinate measurement accuracy theodolite. Additionally, angle theodolite is divided into horizontal vertical components for discussion, obtained by compared analyzed. This paper first introduces formula coplanar intersection, then suggests fu...

Abstract: In this paper, we present a first linear programming (LP) formulation of the vertex colouring problem (VCP). The complexity orders of the number of variables and the number of constraints of the proposed LP are O ( 9 ) and O ( 8 ), respectively, where and are the number of vertices and the number of available colours in the VCP instance, respectively. Hence, the proposed model represe...

We show the feasibility of efficient routing and service discovery in sensor networks using the Virtual Cord Protocol (VCP). Scalable and energy efficient data management is still a challenging topic in this domain. Recently, the advantages of virtual coordinates have been explored in comparison to solutions based on geographical positions. Due to the fact that such virtual coordinates can be a...

During design and implementation of the automatic materials handling system (AMHS) for a local 300mm semiconductor wafer fab (semiconductor fabrication plant), we observed and found an interesting phenomenon Vehicle Clustering Phenomenon (VCP) from the dynamics of automated vehicles: As time evolves, the distance between any two adjacent vehicles usually becomes very close enough as if all the ...

INTRODUCTION The aim of this study was to compare various coplanar and non-coplanar 3-dimensional conformal radiation therapy (3DCRT) beam arrangements for the delivery of stereotactic ablative radiation therapy (SABR) to patients with early stage lung cancer, based on the dosimetric criteria from the Radiation Therapy Oncology Group (RTOG) 1021 protocol. METHODS Ten medically inoperable lung...

Cine films of brown pelicans flying in formation were used to measure altitudes and wing tip spacing (WTS, distance perpendicular to the flight path between wing tips of adjacent birds at maximum span) for birds flying in ground effect, and vertical displacements and WTS for birds flying out of ground effect. Views were near coplanar with the plane of flight paths, and maximum wing span was use...