Pericyte and vascular smooth muscle cell (SMC) recruitment to the developing vasculature is an important step in blood vessel maturation. Brain-derived neurotrophic factor (BDNF), expressed by endothelial cells, activates the receptor tyrosine kinase TrkB to stabilize the cardiac microvasculature in the perinatal period. However, the effects of the BDNF/TrkB signaling on pericytes/SMCs and the ...

Granulomatosis with polyangiitis (GPA) is a small-vessel and medium-vessel vasculitis that affects mainly the respiratory tract and kidney. The main acute complications of GPA are diffuse pulmonary hemorrhage and acute renal failure. Renal involvement occurs in 17% of patients, with histological features of pauci-immune, focal, and segmental necrotizing crescentic glomerulonephritis.1 Diffuse a...

Discussion Our patient fulfills all the American College of Rheumatology criteria for TA [5] , and vessel vasculitis was histologically proven. Arterial dissection in TA is rare [2, 6] , with few reports of aortic dissection [7] and only one report of ICA dissection [8] . In our patient, at the moment of ICA dissection, all the other aortic archs and their branches were angiographically normal ...

Morphine, a highly potent analgesic agent, is frequently prescribed for moderate to severe cancer pain. In this study, morphine was administered at a clinically relevant analgesic dose to assess tumor cell-induced angiogenesis and subcutaneous tumor growth in nude mice using mouse Lewis lung carcinoma cells (LLCs). Implantation of mice with a continuous slow-release morphine pellet achieved mor...

PURPOSE The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonectomy and standard lymphadenectomy between 1999 and 2003. Patients were rando...

various studies have been conducted to study the relationship between job involvement and organizational citizenship behavior but a very little work have been done to study the impact of both job involvement and organizational commitment on “organizational citizenship behavior”. thus the purpose of the study is to find out the relationship between job involvement, organizational commitment and ...

Ocular involvement in the acute phase of Kawasaki disease typically involves the anterior segment of the eye, and its associated treatment outcomes are generally excellent. However, there are rare reports of posterior segment involvement, and these are associated with poorer outcomes. This study reviewed six patients with recently reported blindness and/or ocular posterior segment involvement i...

INTRODUCTION Limited information is available regarding the relationship between coronary vessel dominance and atherosclerotic involvement. Rheological factors have been implicated in the pathogenesis of coronary lesions. More than 90% of the coronary blood flow enters the left coronary if it is the dominant artery. The main purpose of this study was to determine the relation between left coron...

BACKGROUND/AIMS Churg-Strauss syndrome (CSS) is a rare systemic necrotizing small-vessel vasculitis, with accompanying bronchial asthma, eosinophilia, and eosinophilic infiltration of various tissues. The purposes of our study were to characterize the clinical features of CSS and to identify factors associated with CSS prognosis in Koreans. METHODS Medical records were reviewed retrospectivel...