The potassium channel antagonist 4-aminopyridine (4-AP) improves a variety of motor abnormalities associated with disorders of the cerebellum. The most rigorous quantitative data relate to 4-AP's ability to improve eye movement deficits in humans referable to dysfunction of the cerebellar flocculus. Largely based on work in the ataxic mouse mutant tottering (which carries a mutation of the Cacn...

Human postural control is regulated by the vestibular, somatosensory, and visual systems. These types of sensory information are integrated in central nervous system to ascertain body’s position space. Proper functioning senses necessary for body maintain equilibrium. Bilateral vestibulopathy (BVP) a condition which bilateral peripheral vestibular function reduced. Its treatment includes rehabi...

OBJECTIVE To assess vestibular function in a large group of vestibular schwannoma patients so that we could determine whether simple vestibular exercises speed vestibular dysfunction recovery after tumor removal surgery. STUDY DESIGN A prospective investigation of the vestibular dysfunction experienced by patients in the first 12 weeks after surgery. SETTING Vestibular investigation unit at...

The firing behavior of seven antidromically identified ascending tract of Deiters (ATD) neurons was recorded in one alert squirrel monkey trained to pursue moving targets and to fixate visual targets at different distances from the head during whole body rotation. 2. ATD cells generated signals related to contralateral horizontal smooth pursuit eye movements and to ipsilateral angular and linea...

The identification of ocular tremor in a small cohort of patients with Parkinson's disease (PD) had lay somewhat dormant until the recent report of a pervasive ocular tremor as a universal finding in a large PD cohort that was, however, generally absent from a cohort of age-matched healthy subjects. The reported tremor had frequency characteristics similar to those of PD limb tremor, but the am...