Vinca alkaloids are used widely in the treatment of both childhood and adult cancers. Their cellular target is the beta-tubulin subunit of alpha/beta-tubulin heterodimers, and they act to inhibit cell division by disrupting microtubule dynamics. Despite the effectiveness of these agents, drug resistance is a major clinical problem. To identify the underlying mechanisms behind vinca alkaloid res...

Clonostachys rosea is a potential biocontrol fungus that can produce highly resistant chlamydospores under specific conditions. To investigate the genes related to chlamydospore formation, we identified reliable reference genes for quantification of gene expression in C. rosea 67-1 during sporulation. In this study, nine reference genes, actin (ACT), elongation factor 1 (EF1), glyceraldehyde-3-...

T HE Medical Research Council's investigation into pityriasis rosea in 1959 has already been published (Proc. roy. Soc. Med., 55, 556). This second investigation, based on a very simple questionnaire, has produced some additional information, but has not altogether solved the question put, namely "What is the cause of this disease?" Much interest was shown. In 1964, 180 observers notified 531 c...

PURPOSE This study is the first clinical trial aiming to explore the clinical outcomes in burnout patients treated with Rhodiola rosea. The reported capacity of R. rosea to strengthen the organism against stress and its good tolerability offer a promising approach in the treatment of stress-related burnout. The aim of the treatment was to increase stress resistance, thus addressing the source r...

lesser periwinkle (vinca minor l.), a member of apocynaceae, is not only an ornamental plant with lilac-blue flowers, but also a medical plant producing an important alkaloid, vincamine, found in the leaves which shows a pronounced cerebrovasodilatory and neuroprotective activity. this plant is native to northern spain, western france, central and southern europe, and caucasus. it has been rece...

E2F3 encodes a transcription factor important for cell cycle regulation and DNA replication. It plays a significant role in the development of various types of human cancer. Genomics and proteomics features of the tumor marker have a pronounced significance in the pharmainformatics studies. The crystal structure of E2F3 is not available in any structural database; hence a 3D structure is very e...

The aim of this study was to evaluate plant extracts for antifungal activities against Phythopthora infestans (Mont.) de Bary, an important pathogen of potato which causes late blight disease. Acetone, ethyl acetate and water extracts of garlic (Allium sativum L.), Pawpaw (Carica papaya), Neem (Azadirachta indica), Mexican marigold (Tagetes minuta) and peri –winkle (Vinca rosea) were screened i...