Kromatografi pasangan ion dapat digunakan untuk meretensi senyawa yang memiliki muatan, bersifat polar dan memisahkan analit bervariasi kepolaran hidrofobisitasnya. Hal tidak dilakukan dengan mudah pada metode kromatografi fase balik biasa. Pemisahan kolom menggunakan menganalisa kadar Thiamine Mononitrat (Vitamin B1), Pyridoxine HCl B6) Cyanocobalamin B12) secara simultan. Validasi juga membuk...

OBJECTIVE To assess whether adolescents with high body mass index (BMI), or fat mass index (FMI), in combination with insulin resistance (assessed with the Homeostatic Model Assessment [HOMA] index), had also lower blood vitamin B6, folate and vitamin B12 concentrations. METHODS AND MATERIALS Six hundred and fifteen adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence ...

A multifaceted analysis of the nutritional status of 196 subjects, aged over 65, institutionalized in hospitals, residential accomodation, and sheltered dwellings and of noninstituionalized subjects was untaken. Subjects of hospital and home, with or without multivitamin supplementation, were grouped separately. The study comprised of 3-day weighed dietary record, biochemical determinations, an...

Background: Evidence from experimental and epidemiologic studies suggests that vitamin B6 may reduce the risk of breast cancer. Methods: We examined the association of prediagnostic plasma concentrations of pyridoxal-50-phosphate (PLP), an active form of vitamin B6, with postmenopausal breast cancer risk in a case–control study nested in the multiethnic cohort in Hawaii and Southern California,...

The physiologically active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is known to function as a cofactor in many enzymic reactions in amino acid metabolism. Recent studies have shown that, apart from its role as a coenzyme, PLP acts as a modulator of steroid hormone receptor-mediated gene expression. Specifically, elevation of intracellular PLP leads to a decreased transcriptional respon...

OBJECTIVE The aim of this study was to evaluate plasma homocysteine (Hcy), malondialdehyde (MDA), glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) activities and liver tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) levels in control and vitamin B6-deficient rats. MATERIALS AND METHODS Thirty-two male rats with a weight of 65-75 ...

OBJECTIVE Ionic magnesium (Mg(2+)) depletion has long been known to cause hyperexcitability with convulsive seizures in rodents, effects that have been reversed by treatment with magnesium (Mg). Metabolic disorders and genetic alterations are suspected in this pathology, in which Mg(2+) transport and intracellular distribution may be reduced without change in serum Mg(2+) concentrations. We eva...

Assessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B6 with ovarian cancer risk among 80,254 Nurses’ Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian c...

Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140-145 g, were divided into five groups: control, triton, gra...