BACKGROUND The effect of compression on the physis is generally defined by the Hueter-Volkmann principle, in which decreased linear growth of the physis results from increased compression. This investigation examined whether mechanically induced compression of rabbit physes causes changes in gene expression, cells, and extracellular components that promote physeal resilience and strength (type-...

objective(s): in this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  materials and methods: paclitaxel (ptx) loaded polylactic acid (pla) nanofibers were prepared by electrospinning. the effects of process parameters, such as ptx concentration, tip to collector distance, voltage, temperature and flow rate...

objective: amphotericin b (amb) is an ancient antifungal drug and proper for treatment of systemic fungal infection. unfortunately, this antibiotic has shown some side effects such as nephrotoxicity. therefore, recently new amb formulated has been prepared for reduced toxicity and increased effectiveness. materials and methods: amb nanocapsules prepared from polymers such as poly d, l-lactide-...

INTRODUCTION I N earlier work it was found that the addition of excess of vitamin A (10 i.u./ml.) to the culture medium produces drastic changes in embryonic limb-bones and skin in organ culture. The matrix of cartilage (mouse, chick) and bone (mouse) rapidly disappears (Fell & Mellanby, 1952; Fell, Mellanby, & Pelc, 1956) and in the epidermis of skin from 7 to 18-day chick embryos (Fell & Mell...

During salamander limb regeneration, nerves provide signals that induce the formation of a mass of proliferative cells called the blastema. To better understand these signals, we developed a blastema-dorsal root ganglia (DRG) co-culture model system to test the hypothesis that nerves differentially express genes in response to cues provided by the blastema. DRG with proximal and distal nerve tr...

Transient disturbances were applied to the lower limbs of infants (3-10 mo of age) while they were supported to stepped on a treadmill. The aim was to determine how stepping infants respond to novel disturbances that would disrupt equilibrium during independent walking. Their responses were also compared with those from lower mammals and adult humans. In the first series of experiments, the mot...

INTRODUCTION I N earlier work it was found that the addition of excess of vitamin A (10 i.u./ml.) to the culture medium produces drastic changes in embryonic limb-bones and skin in organ culture. The matrix of cartilage (mouse, chick) and bone (mouse) rapidly disappears (Fell & Mellanby, 1952; Fell, Mellanby, & Pelc, 1956) and in the epidermis of skin from 7 to 18-day chick embryos (Fell & Mell...

Objective(s): In this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  Materials and Methods: Paclitaxel (PTX) loaded polylactic acid (PLA) nanofibers were prepared by electrospinning. The effects of process parameters, such as PTX concentration, tip to collector distance, voltage, temperature and flow rate...

Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...

Upregulation of CGRP-immunoreactive (IR) primary afferent nerve fibers accompanied by mastocytosis is characteristic for the Schistosoma mansoni-infected murine ileum. These mucosal mast cells (MMC) and CGRP-IR fibers, which originate from dorsal root (DRG) and nodose ganglia, are found in close apposition. We examined interactions between primary cultured MMC and CGRP-IR DRG neurons in vitro b...