Borrelia mayonii, a Borrelia burgdorferi sensu lato (Bbsl) genospecies, was recently identified as a cause of Lyme borreliosis (LB) among patients from the upper midwestern United States. By microscopy and PCR, spirochete/genome loads in infected patients were estimated at 105 to 106 per milliliter of blood. Here, we present the full chromosome and plasmid sequences of two B. mayonii isolates, ...

The loss of linear plasmid lp28-1, which contains the vls antigenic variation locus, is associated with reduced infectivity of Borrelia burgdorferi in immunocompetent mice. The recombinant shuttle vector pBBE22, which includes the virulence determinant BBE22 from lp25 and restores infectivity to readily transformable B. burgdorferi lacking lp25 and lp56, was used to determine the effect of tran...

IgG-RFB4-SMPT-dgA consists of deglycosylated ricin A chain (dgA) coupled to the monoclonal antihuman CD22 antibody, RFB4. This study determined the maximally tolerated dose (MTD) of this immunotoxin (IT) administered as a continuous 8-day infusion to 18 patients with B-cell lymphoma (30% CD22+ tumor cells) over 8 days. The MTD was 19.2 mg/m2/192 h (maximum toxicity grade 1), with vascular leak ...

Automatic damage assessment by analysing UAV-derived 3D point clouds provides fast information on the situation after an earthquake. However, of different grades is challenging given variety in characteristics and limited transferability methods to other geographic regions or data sources. We present a novel change-based approach automatically assess multi-class building from real-world using m...

Keywords: Metalorganic chemical vapor deposition (MOCVD) Metal–oxide–semiconductor field effect transistor (MOSFET) Nanowire a b s t r a c t Depletion-mode metal–oxide–semiconductor field effect transistors (MOSFETs) with GaAs planar nano-wire (NW) channels are successfully demonstrated. The Si-doped planar GaAs NWs are grown in a selective lateral epitaxy manner via Au-assisted vapor–liquid–so...

The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that ...

PURPOSE This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors. The study also investigated antitumor activity and provided pharmacokinetic and pharmacodynamic data. EXPERIMENTAL DESIGN Sixteen patients were assigned sequentially to escalating doses of SJG...

Background: Benign vocal fold lesions (BVFLs) are usually caused by abuse or misuse. Conservative treatment and micro laryngeal surgery (MLS) recommended in the treatment. However, conservative measures difficult to perform some patients contraindicated for general anesthesia.Objective: This study is designed assess practical application, effectiveness, side effects of office-based steriod inje...

The vapor–liquid–solid (VLS) method is considered a plausible technique for synthesizing germanium (Ge) nanostructures (e.g., nanowires), which have broad range of applications due to their unique electronic properties and intrinsic compatibility with silicon. However, crystallization failures material defects are still frequently observed in VLS processes, insufficient understanding underlying...

CuInSe2 nanoparticles have been prepared by reacting cuprous chloride, indium chloride with alcohol and selenium powder. The nanoparticles were characterized by TEM, XRD, ICP-OES and SEM. The formation of CuInSe2 nanoparticles with different precursor ratios was investigated by in-situ high temperature X-ray diffraction analysis. It was found that the growth of CIS followed a vapor-liquid-solid...