dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (vm) and the michaelis-menten constant (km) in a concerned population. the aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of iranian patients to optimize the antiepileptic pharmacotherapy. fourty patients who received a constant dose of phenytoin ...

The Drosophila visceral mesoderm (VM) is a favorite system for studying the regulation of target genes by Hox proteins. The VM is formed by cells from only the anterior subdivision of each mesodermal parasegment (PS). We show here that the VM itself acquires modular anterior-posterior subdivisions similar to those found in the ectoderm. As VM progenitors merge to form a continuous band running ...

Visual management (VM) is the managerial strategy of consciously integrating visual tools in workspaces with the aim of increasing transparency on construction sites. Several VM tools and approaches that had been originally developed in the manufacturing context were implemented in construction. However, research on the application of VM in construction as a managerial strategy is scarce. This ...

A novel series of milbemycin antibiotics were isolated from the fermentation broth of a Streptomyces species designated E225. The structures of the four main metabolites VM 44857 (1), VM 44864 (2), VM 44865 (3) and VM 44866 (4) were determined by NMR techniques. In addition we describe the solution conformations of the major metabolite VM 44857 (1).

PURPOSE To investigate whether patients with vestibular migraine (VM) are more susceptible to carsickness than patients with non-vestibular migraine (NVM) or Meniere's disease (MD). METHODS Consecutive patients with a diagnosis of definite VM, probable VM, NVM, or MD at our Headache and Dizziness clinics were interviewed using the same three questions to investigate the history of carsickness...

Vasculogenic mimicry (VM) refers to the condition in which tumour cells mimic endothelial cells to form extracellular matrix-rich tubular channels. VM is more extensive in more aggressive tumours. The human epidermal growth factor receptor 2 (HER2) gene is amplified in 20-30% of human breast cancers and has been implicated in mediating aggressive tumour growth and metastasis. However, thus far,...

INTRODUCTION In order to interpret ST-segment changes as an indicator of ischemia in patients with higher heart rates (HRs), the relation between ST-segment levels and HR needs to be well defined in subjects without coronary artery disease. METHODS Eighteen patients with normal ECGs in the catheterization laboratory, after radiofrequency ablation of AV nodal re-entry tachycardia or an accesso...

Abstract VM consolidation has been proposed as an effective solution to improve resource utilization and energy efficiency through migration. Improper placement during may cause frequent migrations constant on–off switching of PMs, which can significantly hurt QoS increase consumption. Most existing algorithms on efficient suffer the problem easily falling into a sub-optimum prematurely since t...

Verbal memory (VM) represents one of the most affected cognitive domains in schizophrenia. Multiple studies have shown that schizophrenia is associated with cortical abnormalities, but it remains unclear whether these are related to VM impairments. Considering the vast literature demonstrating the role of the frontal cortex, the parahippocampal cortex, and the hippocampus in VM, we examined the...