Vasculogenic mimicry (VM) plays an important role in colorectal cancer (CRC) metastasis, and both hypoxia and the epithelial-mesenchymal transition (EMT) are necessary for VM. In this study, HIF-1α expression was upregulated in the VM-positive CRC cell line HCT-116 and thereby affected the expression of the EMT-related markers Claudin-4, E-cadherin (E-cd) and Vimentin(VIM). SB431542 and U0126Et...

Vasculogenic mimicry (VM) is a brand-new tumour vascular paradigm independent of angiogenesis that describes the specific capacity of aggressive cancer cells to form vessel-like networks that provide adequate blood supply for tumour growth. A variety of molecule mechanisms and signal pathways participate in VM induction. Additionally, cancer stem cell and epithelial-mesenchymal transitions are ...

As cloud computing becomes more popular, collections of virtual machine (VM) images are growing in size. Management of VM collections requires the ability to inspect and search data stored within VM images. We present a plug-in-based architecture, called Manna, for efficiently searching state within VM images through both index and non-index based search. The architecture offers a flexible fram...

Teniposide (VM-26) and etoposide (VP-16-213) were eval uated for their effects on methotrexate transport and metabo lism in Ehrlich ascites tumor cells in vitro. VM-26 (10 JUM)does not alter influx of methotrexate but slows efflux of the drug which leads to an increase in the steady-state level of ex changeable antifolate. VM-26 stimulation of net methotrexate transport occurs within 5 min of e...

Menière's disease and vestibular migraine (VM) are the most common causes of spontaneous recurrent vertigo. The current diagnostic criteria for the two disorders are mainly based on patients' symptoms, and no biological marker is available. When applying these criteria, an overlap of the two disorders is occasionally observed in clinical practice. Therefore, the present prospective multicenter ...

ion channels play a major role in the regulation of t cell function in health and disease. in a computer-based model, established to simulate t cells’ membrane potential (vm) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. the predicted vm was more hyperpolarized than the measured vm, indicating that a yet unknown, depolarizing ion current might contri...

In cloud networks, sharing network resources among different VMs is critical to performance isolation. A sharing scheme aims to fully utilize the network resource, and effectively prevent performance interference and even malicious attacks such as Denial-of-Service (DoS) attacks. Existing bandwidth allocation schemes like Seawall attempt to achieve performance isolation on a per-link basis. How...

The influence of the Valsalva maneuver (VM) on myocardial ischemia was evaluated in 24 patients with coronary heart disease. Clinical and hemodynamic responses to the VM were studied during acute ischemia manifested by angina pectoris with transient left ventricular (LV) dysfunction and compared with responses during nonischemic intervals. In the absence of evidence for acute ischemia (angina a...

The value of video-electroencephalographic monitoring (EEG-VM) in evaluating patients with epileptic disorders constitutes a major research field. This study investigates the usefulness of inpatient long-term EEG-VM for pediatric neurology patients under four headings: pre-surgical evaluation; seizure classification; epileptic seizure and non-epileptic paroxysmal event differentiation; and anti...

are located between the Purkinje and the ventricular (V) cells at these P-VM junction sites. It has been shown that exposure to elevated [K'], in combination with hypoxia produces an increase in the P-VM conduction time. To examine this increase in P-VM conduction time, simultaneous measurements of the action potential upstrokes of T cells and the activation times of the local P and V cells at ...