Changes in central fatigue have been linked to active and passive changes in core temperature, as well as integration of sensory feedback from thermoreceptors in the skin. However, the effects of muscle temperature (Tm), and thereby metaboreceptor and local afferent nerve temperature, on central fatigue (measured using voluntary activation percentage) during sustained, high muscle fatigue exerc...

After a brief introduction on electrostimulation methodology and applications in competititve sport for performance optimization, this technical report presents the principal effects of electrostimulation-induced resistance exercise on neuromuscular features. The advantages and limitations of this technique compared with those of voluntary exercise training are also discussed.

[Purpose] During exercise, skeletal muscle motor units are recruited based on afferent sensory input following peripheral metabolic by-product accumulation. The purpose of this study was to investigate whether lactate plays a role in conveying fatigue-related information to the brain. [Subjects] Eleven healthy adults participated in this study. [Methods] Subjects performed handgrip exercises at...

  Background: The aim of this study was to investigate muscle damage indicators and electromyography activities of quadriceps muscles at 25° of hip flexion in untrained healthy females after an eccentric exercise induced muscle fiber damage.   Methods : A total of 14 healthy females participated in this pre-experimental study. The subjects performed maximal eccentric quadriceps contractions at ...

Both clinical and animal studies suggest that exercise may be an effective way to manage inflammatory and neuropathic pain conditions. However, existing animal studies commonly use forced exercise paradigms that incorporate varying degrees of stress, which itself can elicit analgesia, and thus may complicate the interpretation of the effects of exercise on pain. We investigated the analgesic po...

We examined whether a sympathetic cholinergic mechanism contributed to increased blood flow of the exercising muscle at the onset of voluntary static exercise in conscious cats. After six cats were operantly conditioned to perform static bar press exercise with a forelimb while maintaining a sitting posture, a Transonic or pulsed Doppler flow probe was implanted on the brachial artery of the ex...

During fatiguing upper limb exercise, maintained firing of group III/IV muscle afferents can limit voluntary drive to muscles within the same limb. It is not known if this effect occurs in the lower limb. We investigated the effects of group III/IV muscle afferent firing from fatigued ipsilateral and contralateral extensor muscles and ipsilateral flexor muscles of the knee on voluntary activati...

We investigated whether voluntary exercise and concurrent antidepressant treatment (tianeptine; 20 mg/kg/day; 4 weeks) exert synergistic effects on the mouse hypothalamic-pituitary-adrenocortical (HPA) axis. Animals had access to a running wheel, were treated with the antidepressant, or received both conditions combined. Control mice received no running wheel and no drug treatment. Exercise res...

Lemieux, Andrew M., Cody J. Diehl, Julie A. Sloniger, and Erik J. Henriksen. Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats. J Appl Physiol 99: 357–362, 2005. First published February 17, 2005; doi:10.1152/japplphysiol.00100.2005.— Male heterozygous TG(mREN2)27 rats (TGR) overexpress a murine renin transgene, ...

Objective: Despite the indubitable beneficial effect of exercise to prevent of cardiovascular diseases, there is still a lack of studies investigating the impact of exercise in non-ischemic dilated cardiomyopathy. Here, we investigated the impact of voluntary exercise on cardiac function in a mouse model of non-ischemic dilated cardiomyopathy (αMHC-MerCreMer:Sf/Sf), induced by cardiac-specific ...