Gabriella Lillsunde Larsson (2014): Characterization of HPV-induced vaginal and vulvar carcinoma. Örebro Studies in Medicine 112. Vaginal and vulvar carcinomas are rare gynaecological malignancies, partly caused by the human papilloma virus (HPV). HPV-16 is the most frequent genotype found and HPV as a prognostic factor for these women has not been fully investigated. A persistent HPV-infection...

Cigarette smoking is an established cofactor to human papillomavirus (HPV) in the development of cervical and vulvar squamous cell carcinoma (SCC), and may influence risk through an immunosuppressive pathway. Genetic variation in interleukin 2 (IL2), associated in some studies with the inhibition of HPV-targeted immunity, may modify the effect of smoking on the risk of HPV-related anogenital ca...

OBJECTIVES High morbidity of elective inguinofemoral lymphadenectomy in early stage vulvar cancer patients urges the need for defining a group of low-risk patients in whom inguinofemoral lymphadenectomy can be safely omitted. Aim of the study was to evaluate whether in addition to 'classic' clinicopathological factors determination of EGFR expression in vulvar cancer can be helpful in defining ...

This meta-analysis investigated human papillomavirus (HPV) prevalence in vulvar, vaginal and anal intraepithelial neoplasia (VIN, VAIN, AIN) grades 1-3 and carcinoma from 93 studies conducted in 4 continents and using PCR assays. Overall HPV prevalence was 67.8%, 85.3% and 40.4% among 90 VIN1, 1,061 VIN2/3 and 1,873 vulvar carcinomas; 100%, 90.1% and 69.9% among 107 VAIN1, 191 VAIN2/3 and 136 v...

Vulvar epithelioid hemangioendothelioma as primary site is extremely rare tumor that may be confused with other mesenchymal tumors due to their rarity and its histologic features. We report a case of 46-year-old woman who presented to hospital with left vulvar mass. The mass was located in subcutaneous area of vulva, and well marginated contrast enhanced on radiologic examination. Local excisio...

Vulvar skin disease is a common reason for consultation. The vulva, like the rest of the skin, can be affected by numerous diseases of various etiologies, but its particular anatomic and physiologic characteristics create additional diagnostic and therapeutic difficulties. The study of vulvar disease is emerging as a new branch of dermatology. In this article, we examine the characteristics of ...