Cellular systems are designed to support voice service over the wireless channel but nowadays data-only networks such as cdma2000 1x EV-DO and high speed downlink packet access (HSDPA) are being deployed in the midst of evolution to the next generation wireless networks. Such systems become important because data services are essential in future wireless networks that are supposed to adopt the ...

Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in Gl. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild-type p53 protein in either human or murine cells markedly increases expression of cyclin Dl. The i...

The LEC rat is an inbred mutant strain which spontaneously develops liver injury and subsequent liver cancer. Liver injury in LEC rats has recently been shown to be closely related to abnormal copper accumulation in the liver. Previously, we reported that LEC rat hepatocytes lose their growth potential, probably allowing selective growth of preneoplastic cells. In this study, to elucidate the e...

The article analyzes modern methods and tools used for security testing of web applications. prevalence violations applications the importance their prevention made an integral part software development life cycle (SDLC), which should detect vulnerabilities associated with providing a holistic approach to protecting program from hacker attacks, viruses, unauthorized access confidential data. To...

P53 status may be a determinant of chemosensitivity of tumor cells; however, its involvement in cellular resistance to cisplatin remains uncertain. To investigate the relationships between p53 and the development of resistance to cisplatin, the p53 gene status was studied in ovarian carcinoma cell systems which included two cisplatin-resistant variants (IGROV-1/Pt 0.5 and IGROV-1/Pt 1) selected...

This study investigated the combined immunoexpression of p53, p21, bcl-2, bax, Rb and Ki67 proteins in colorectal adenocarcinomas and correlated expression patterns with tumour stage and grade. Paraffin sections from 98 cases of colorectal adenocarcinomas were stained by immunohistochemistry for p53, p21, bcl-2, bax, Rb and MIB-1 (Ki67) proteins. In addition, 12 cases of colorectal adenomas and...

The role of endothelial cells in pathological processes is the focus of intensive research. In this context, programmed cell death (apoptosis) plays an important function. Although apoptosis can be seen in many instances as detrimental in the cardiovascular system, it also has beneficial functions. For example, the occurrence of endothelial cell apoptosis has deleterious effects on the developm...

Cell cycle, apoptosis, and replicative senescence are all influenced by the cyclin-dependent kinase inhibitor, p21. It was previously reported that deletion of p21 in 129/Sv x C57BL/6 mixed genetic background mice induced a severe lupus-like disease, almost exclusively in females. However, we did not confirm this finding in an independently derived stock of 129/Sv x C57BL/6 p21(-/-) mice. To fu...

The increased potential for contamination of seawater by crude oils requires studies bacterial biodegradation potential, but little is known the differential negative impacts on growth. No two wells generate chemically identical oils; and importantly, solar exposure oil may differentially affect response. Elucidating role that sunlight plays toxicity spilled imperative to understanding how spil...