The reproducibility of exhaled breath condensate (EBC) mediators is not well documented in chronic obstructive pulmonary disease (COPD). This study assessed within assay (WA), within (WD) and between day (BD) reproducibility of EBC leukotriene B4 (LTB4) and 8-isoprostane. Three EBC samples were collected from 24 COPD patients separated by 1 h and 1 wk, to assess WD and BD reproducibility. WA re...

Recently, the authors developed a new synthesis technique for the design of higher-order Bode-type variable-amplitude (VA) wavedigital (WD) equalizers. The salient feature of the resulting VA WD equalizers is that they permit the continuous variation of the WD equalizer transfer function from a shaping transfer function to its inverse by changing the value of a single variable digital multiplie...

BACKGROUND Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B pathogenic mutations. The symptoms of WD can be effectively prevented if the affected individuals are identified and intervened early. However, clinical utility of this molecular analysis is challenging due to hundreds of variants with various clinical effects in the gene. Here, we aim to de...

Background. Whipple’s disease (WD) is an infectious disease caused by Tropheryma whipplei, which replicates in macrophages and induces the release of interleukin (IL)-16, a substrate of caspase 3, and macrophage apoptosis. The disease is characterized by intestinal, cardiac or neurological manifestations; its diagnosis is based on invasive analysis requiring tissue biopsies or cerebrospinal flu...

The gene pkwA coding for a typical WD-repeat protein was found in the chromosome of the bacterium Thermomonospora curvata CCM 3352. Until now WD-repeat proteins were through to be confined to eukaryotes.

Wilson disease (WD) represents a monogenic disease resulting in copper accumulation within tissues. Incidence is estimated to be approximately 1:30 000. Symptoms include acute and chronic liver disease, hemolysis, and neurodegenerative and psychiatric symptoms (1 ). The first symptom may be acute liver failure. Death or liver transplantation in WD is common. The European Liver Transplant Regist...

We previously have shown that chronic sodium chloride (NaCl) loading protects against HgCl2-induced acute renal failure (ARF) in dogs. To determine whether NaCl loading protects against an ischemic model of ARF, unilateral oliguric renal failure was produced by the infusion of norepinephrine (NE) into the renal artery of both saline-expanded (SE) and water-drinking (WD) dogs (n = 7). The renal...

Splenomegaly and pancytopenia are common in Wilson's disease (WD) and splenectomy is one of the conventional treatments for splenomegaly and the associated pancytopenia. However, splenectomy remained controversial for hypersplenism in WD as it was reported that splenectomy leaded to serious emotional and neurological deterioration in WD patients with hypersplenism. In the current study, we pres...