28 Background: LAMB2 mutations cause Pierson syndrome (OMIM 609049), an 29 autosomal recessive genetic disease typically characterized by congenital nephrotic 30 syndrome (CNS) and early onset renal failure, as well as bilateral microcoria. 31 NPHP1 mutations cause familial juvenile nephronophthisis type 1 (NPHP1, OMIM 32 256100), another autosomal recessive renal disease that usually occurs ye...