نتایج جستجو برای: weighted gene co expression network analysis
تعداد نتایج: 4838665 فیلتر نتایج به سال:
With unprecedented increase in next generation sequencing technologies, there has been a persistent interest on transcript profiles of long non-coding RNAs (lncRNAs) and protein-coding genes forming an interaction network. Apart from protein-protein interaction (PPI), gene network models such as Weighted Gene Co-expression Network Analysis (WGCNA) are used to functionally annotate lncRNAs in id...
Clear cell renal cell carcinoma (ccRCC) is the most common solid lesion within kidneys, and its prognostic is influenced by the progression covering a complex network of gene interactions. In our study, a weighted gene co‑expression network was constructed to identify gene modules associated with the progression of ccRCC (n=35). In the significant module (R2 = -0.53), a total of 13 network hub ...
Background: Pancreatic ductal adenocarcinoma (PDAC) develops rapidly and has a poor prognosis. It been demonstrated that pancreatic chronic pancreatitis (CP) have close connection. However, the underlying mechanisms for transforming into are still unclear. The purpose of this study was to identify real hub genes in development adenocarcinoma. Methods: RNA-seq data were downloaded from Gene Expr...
BACKGROUND Impaired glutamatergic signaling is believed to underlie auditory cortex pyramidal neuron dendritic spine loss and auditory symptoms in schizophrenia. Many schizophrenia risk loci converge on the synaptic glutamate signaling network. We therefore hypothesized that alterations in glutamate signaling protein expression and co-expression network features are present in schizophrenia. ...
Human bladder cancer (BCa) is one of the worldwide cancers in men and women populations, with the etiology and mechanism unknown. In our study, we constructed a weighted gene co-expression network to identify gene modules associated with the progression of BCa (n = 93). In the significant module (R2 = 0.48), a total of 103 network hub genes were identified, and 4 of them were hub nodes in the p...
BACKGROUND Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death and there is a huge unmet clinical need to identify disease biomarkers in peripheral blood. Compared to gene level differential expression approaches to identify gene signatures, network analyses provide a biologically intuitive approach which leverages the co-expression patterns in the transcr...
Marbling (intramuscular fat) is an important trait that affects meat quality and is a casual factor determining the price of beef in the Korean beef market. It is a complex trait and has many biological pathways related to muscle and fat. There is a need to identify functional modules or genes related to marbling traits and investigate their relationships through a weighted gene co-expression n...
Using floral organs of five pear cultivars as materials, this study determined and compared physiological indices such relative conductivity, superoxide dismutase (SOD), malondialdehyde (MDA) each cultivar’s under different low-temperature stress treatments, evaluated the cold resistance cultivars. Transcriptome sequencing analysis was performed on a new early-ripening cultivar called “Jinguang...
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