We studied the functional role of two mutations, Pro55Ser and Pro55Leu, located in the N-terminal Epidermal Growth Factor-like domain (EGF1) of coagulation factor (F) IX. Both mutations cause mild hemophilia B with habitual FIX coagulant activities of 10-12% and FIX antigen levels of 50%. We found that activation by FVIIa/TF and FXIa was normal for FIXPro55Ser, but resulted in proteolysis of FI...

consisted of chemoradiation therapy in the following manner: Two cycles of Paclitaxel (Taxol®)-Carboplatin followed by Paclitaxel-Carboplatin with radiation therapy (XRT) to the GE junction for six weeks followed by maintenance Folinic Acid-Oxaliplatin-Fluorouracil (FOLFOX 6) every two weeks. Drug dosing was modified in accordance with complete blood count (CBC) results. Serial PET scans were p...

Cellular Entry of Hantaviruses Which Cause Hemorrhagic Fever with Renal Syndrome Is Mediated by b3 Integrins IRINA N. GAVRILOVSKAYA, ERIC J. BROWN, MARK H. GINSBERG, AND ERICH R. MACKOW* Department of Medicine and Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794; Washington University School of Medicine, St. Louis Missou...

The fundamental basis of diabetes continues to go unrecognized and untreated. Depending on the type of diabetes i.e; 1 or 2, treatment consists of insulin injections (1) or antidiabetic drugs that lower blood glucose and hopefully hemoglobin A1C as well (2) Often patients with type 2 are asked to lose weight, exercise more vigorously as well and more frequently. Previously, using a diabeticstre...

In 1994 a batch of apparently healthy goats was selected for intended export to the USA from a heartwater-free and vector tick-free region of South Africa. The animals were tested serologically for heartwater, using either or both an IFA and an ELISA test, and 52% were found to be serologically positive. A PCR assay based on Ehrlichia ruminantium 16S gene sequences gave positive results for 54%...

T N PREVIOUS experiments, we found that •*• serotonin, norepinephrine and their respective precursors, 5-hydroxytryptophan (5HTP) and 3,4-dihydroxyphenylalaninc (DOPA), had qualitatively the same cardiovascular effects as reserpine when they were injected into a cerebral lateral ventricle of anesthetized and unanesthetized dogs. The results were all consistent with the premise that the acute ca...

Several studies have reported rhabdomyolysis induced by various drugs but not by the antiepileptic drug levetiracetam. We present a case of suspected levetiracetam-induced rhabdomyolysis. A 29-year-old woman was hospitalized for generalized tonic-clonic seizure and given levetiracetam for the first time. One day after starting levetiracetam, she developed myalgia, particularly backache, and wea...

PURPOSE Knockdown hammerhead ribozymes were designed to cleave at a sterically accessible site in long expression-competent mutant and normal human rod opsin mRNAs. Ribozyme suppression of mutant mRNA is expected to rescue autosomal dominant retinitis pigmentosa (adRP) caused by rod opsin mutations. METHODS Energy minimization algorithms predicted regions in human rod opsin mRNA accessible to...

E xtensive investigations of the pathophysiology of non-insulin-dependent diabetes mellitus (NIDDM) have identified two defects in endocrine function: insulin resistance and insulin deficiency. Despite general agreement that both defects are present in most patients with established NIDDM, many authorities have debated the question of which defect is the primary cause of NIDDM. Many interesting...

Four Cladobotryum isolates were collected from four different commercially grown mushroom types infected with cobweb disease in Cheongdo-gun and Chilgok-gun of Gyeongbuk Province, Korea in 2010. The isolates were identified as C. mycophilum from Agaricus bisporus and Pleurotus eryngii, C. varium from Flammulina velutipes and Hypsizygus marmoreus. The cultural characteristics of the four isolate...