Transcript prediction can be modeled as a graph problem where exons are modeled as nodes and reads spanning two or more exons are modeled as exon chains. Pacific Biosciences third-generation sequencing technology produces significantly longer reads than earlier second-generation sequencing technologies, which gives valuable information about longer exon chains in a graph. However, with the high...

MOTIVATION The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hash table-based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to align short reads from a single individual. However, MAQ does not support gapped alignment for sin...

Dr. Tredgold has contributed an excellent addition to the literature dealing with Mental Deficiency. His book in great part will repay perusal by the medical profession in general. He is well qualified to write upon this subject, and has accumulated abundant and valuable material based upon personal research. Throughout the book reads concisely and clearly. Where necessary the investigations of...

This article deals with a framework of library economic metrics including service input and output, performance, usage, effectiveness, outcomes, impact, and cost and benefit comparisons. Examples of these measures are given for comparison of library electronic and print collections and collection services based on a recent cost finding study at Drexel University where the library has converted ...

The paper describes a novel approach for filtering duplicate reads from 454 pyrosequencing data. This problem is motivated by the need of reduce sequencing errors and artifically duplicated reads in some applications such as de-novo whole genome sequencing or metagenomics. Existing solutions are often based on nucleotide sequences, while raw flowgram values, which contain additional information...

In this article I studied the undertaking of King Vladislaus II Bohemia (1456– –1516), which he have to oblige became a czech king after death George Poděbrady and demands Czechs expressed on Diet at Kutná Hora.

The aim of the project is to detect and classify the brain tumor from MRI image. This project involves mainly 6 stages namely Input Image, Preprocessing, Segmentation, Post Processing, Feature Extraction and Classification. In this phase, 4 stages are implemented, Input image, preprocessing, segmentation and post processing. Input image reads the MRI brain image. Preprocessing mainly includes i...