Consider the problem of simultaneously testing null hypotheses H1, . . . ,Hs. The usual approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate (FWER), the probability of even one false rejection. In many applications, particularly if s is large, one might be willing to tolerate more than one false rejection provided the nu...

Most of the working solvers for numerical constraint satisfaction problems (NCSPs) are designed to delivering point-wise solutions with an arbitrary accuracy. When there is a continuum of feasible points this might lead to prohibitively verbose representations of the output. In many practical applications, such large sets of solutions express equally relevant alternatives which need to be ident...

The concept of k-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least k false rejections, for some fixed k ≥ 1. A less conservative notion, the k-FDR, has been introduced very recently by Sarkar [Ann. Statist. 34 (2006) 394–415], generalizing the false discovery rate of Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 5...

We evaluate four association tests for rare variants-the combined multivariate and collapsing (CMC) method, two weighted-sum methods, and a variable threshold method-by applying them to the simulated data sets of unrelated individuals in the Genetic Analysis Workshop 17 (GAW17) data. The family-wise error rate (FWER) and average power are used as criteria for evaluation. Our results show that w...

Multiple hypothesis testing is a significant problem in nearly all neuroimaging studies. In order to correct for this phenomena, we require a reliable estimate of the Family-Wise Error Rate (FWER). The well known Bonferroni correction method, while simple to implement, is quite conservative, and can substantially under-power a study because it ignores dependencies between test statistics. Permu...

The problem of multiple testing is rarely addressed in disease mapping or descriptive epidemiology. This issue is relevant when a large number of small areas or diseases are analysed. Control of the family wise error rate (FWER), for example via the Bonferroni correction, is avoided because it leads to loss of statistical power. To overcome such difficulties, control of the false discovery rate...

Hadronic matrix elements are expressed in the framework of BS formalism, and in the limit of heavy quark mass mQ → ∞, we find that all form factors in processes of B → D weak transition can be incorporated into a single universal Isgur-Wise (I −W ) function ξ(v · v′), which was first discovered by Isgur and Wise in heavy quark effective theory (HQET). By introducing a phenomenological interacti...

Most existing methods for QTL mapping in experimental crosses assume that the residual variance is constant across all individuals. But common situations violate this assumption. For many phenotypes, one sex is more variable than the other, some experimenters make more precise measurements than others, and specific genetic factors influence environmental sensitivity. In these cases, mean-varian...

BD-SIIT and DSTM are widely deployed IPv4/IPv6 Transition mechanism to improve the performance of the computer network in terms of Throughput,End to End Delay(EED) and Packet Drop Rate(PDR).In this journal paper we have Implemented and Compared the Performance Issues of our newly proposed Dollops Wise Curtail(DW&C)IPv4/IPv6 Migration Mechanism with BD-SIIT and DSTM in NS2. Implementation and Co...