Because our previous studies indicated that squalestatin 1 treatment induces CYP2B expression in primary cultures of rat hepatocytes as a direct consequence of squalene synthase inhibition, we investigated possible underlying mechanisms. Cotransfection of cultured Sprague-Dawley male rat hepatocytes with each of the three sterol regulatory element binding protein (SREBP) transcription factors f...

Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia. Materials methods. for study were samples active pharmaceutical ingredients based (Fe(III) hydroxide complexes with polymaltose): HA-Fe 3+ , HA-PMFe FA-Fe FA-PM-Fe . The anti-anemic activity was studied 53 female Wistar rats conventional rat line model posthe...

In the present study, relation between bone, cartilage and titanium was analyzed. According to established methodology, homogeneous grafts conserved in alcohol 100 GL for 7 days were used, after fixation of a homologous graft above bone cortical rat femur (Rattus novergicus var. Albinus rodentia mammalia cepa Wistar), using screw implant. The animals sacrificed at 10, 20, 30 60 surgery. To hist...

The borderline hypertensive rat is the first filial offspring of the spontaneously hypertensive rat and the Wistar-Kyoto rat. In response to acute environmental stress (air jet), the borderline hypertensive rat exhibits a diuretic response, whereas the parental strains exhibit an antidiuretic response (spontaneously hypertensive rat) or no change in urine flow rate (Wistar-Kyoto rat). This stud...

background and objective: the effect of opioids on the reproductive system has been studied as an attractive research field. in this study, the effect of morphine as an analgesic opioid was evaluated on the ovarian polycystic induction in the rat. materials & methods: in this study, 24 female virgin wistar rats weighing 200-250 g were injected with morphine (1-10 mg/kg/day) for 9 days. cont...

Let V be a compact, oriented 2n-dimensional (C--)differentiable manifold. If V admits a complex structure, compatible with its differentiable structure, the structural group of the tangent bundle of V can be restricted in a natural way from GL(2n,R) to GL(n,C). This gives for V a necessary condition of topological nature, which led Ch. Ehresmann and H. Hopf some 20 years ago to the concept of a...

A significant proportion of aged humans may have impaired thirst and inadequate fluid intake after a period of fluid deprivation. We have studied the water drinking responses, relative to body weight, of Munich Wistar (MW) rats in response to osmotic, hypovolemic, dehydrational, and angiotensin (Ang)-related stimuli as they aged from 3 to 24 months. Young 3-months-old (m.o.) rats had the larges...

AIM To evaluate the protective and ameliorative effect of aqueous sea buckthorn leaf extract (SLE) on hemato-biochemical profile in lead intoxicated Wistar rats. MATERIALS AND METHODS An experiment was conducted for 60 days. 36 adult male Wistar rats with a mean body weight of 177.8±12.6 g were divided into five groups and were subjected to various daily oral treatment regimens. Group I serve...

Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê roxo") on the blood and liver cells of Wistar rats was evaluated. Experimenta...

BACKGROUND Kolaviron, isolated from seeds of Garcinia kola, have been shown to possess wide pharmacological properties. PURPOSE The present study examined the effect of kolaviron on acetylcholinesterase activities in the hippocampus and striatum of adult Wistar rats. METHODS In this study, histological and histochemical methods were used to investigate the effects of kolaviron on the histol...