A newly established gastric carcinoma cell line (EPG85-257P) exhib ited a high sensitivity to mitoxantrone (DHAD) as determined by a monolayer proliferation assay. The concentration to inhibit cell growth to 50% of controls (IG»)was 0.0022 «¿g/ml culture medium. The cells were continuously incubated for more than 4 months in the presence of stepwise increased concentrations of DHAD, and the ...

supplemented with 10% horse serum. The cells grew ex ponentially with a doubling time of 16 to 17 hours, had a cell volume (mean ±S.E.) of 2313 ±89 cu /tm, and were cloned in soft agar with a cloning efficiency of 68.7 ±6.3%. Sensitivity to the alkylating agent nitrogen mustard (HN2) was comparable to that observed previously with LSI78Y murine lymphoblasts; the D0 (the dose of drug reducing...

‚√§μ‘¥‡TM◊ÈÕπ‘a“À剫√— ®—¥‡aìπ‚√§Õÿ∫—μ‘ „À¡à∑’Ëæ∫„π‡¢μ‡Õ‡TM’¬μ–«—πÕÕ°‡©’¬ß„μâ ‡TM◊È Õ‰«√— π’È¡—°æ∫Õ¬Ÿà „π§â“ߧ“«„π °ÿ≈ Pteropus ‚¥¬¡’°“√·æ√à Ÿà§π·≈– ÿ°√‡aìπ §√—Èߧ√“« ·≈–∫“ߧ√—Èß·æ√à‰a¬—ß —μ«å‡≈’È¬ß TMπ‘ ¥Õ◊Ë π‰¥â ¥â «¬ ‡TM◊È Õ‰«√— π’È ¡’ °“√√“¬ß“π‡aì π §√—È ß·√°‡¡◊Ë Õ‡°‘ ¥°“√√–∫“¥Õ¬à “ß·æ√à À≈“¬„π ¡“‡≈‡ ́’ ¬„πaï æ.». 2541-2542 Õ¬à “ß‰√°Á μ“¡ ‡TM◊ËÕ«à“‡TM◊ÈÕ‰«√— π’È¡’°“√·æ√à°√–®“¬Õ¬Ÿà„π ÿ °√‡≈’È...

The aggregation of the â-peptide into amyloid is a key pathological event in Alzheimer’s disease. This process (â-amyloidosis) involves the conversion of soluble random coil, R-helical or â-sheet conformations into insoluble, aggregated â-pleated sheet structures. The pH is a significant extrinsic factor that influences â-amyloidosis, which must be related to the presence of ionizable groups in...

Daya Hantar Listrik (DHL) atau konduktivitas dalam air  menunjukkan banyaknya kandungan ion-ion terlarut tersebut. Pemukiman penduduk di Tempat Pembuangan Akhir (TPA) Sukawinatan Palembang, sangat rentan akan pencemaran dari lindi sampah yang masuk ke sumur pemukiman masyarakat setempat. Parameter DHL dapat ditentukan dengan enggunakan Rangkaian Jembatan Wheatstone (RJW). Penelitian ini bertuj...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

Overexpression of the epithelial specific matrix metalloproteinase inatrilysin (MAT) has been correlated with enhanced tumorigenicity and tumor cell invasion using in vitro model systems. We have determined the effects of MAT expression on the development of mammary tumorigenesis using transgenic mice that express human MAT under the control of the mouse mammary tumor virus (MMTV)-long terminal...

We suggest and investigate a scheme for non-deterministic noiseless linear amplification of coherent states using successive photon addition, (â(†))(2), where â(†) is the photon creation operator. We compare it with a previous proposal using the photon addition-then-subtraction, ââ(†), where â is the photon annihilation operator, that works as an appropriate amplifier only for weak light fields...

Amitriptyline and Perphenazine in depressive ill ness: a controlled trial. I. Haider . . . . 195 Amnesic syndrome, the Grunthal-Störrmg case of.0. L. Zangwill .. .. .. .. i13 701 —¿ ————,—(C) .. .. .. .. 557 Amylobarbitone, cross-over study with Trimi 701 pramine. J. W. Hunter et a!. . . . . . . 667 —¿ sodium, controlled comparison with nitraze 383 pam (†̃Mogadon'). C. Davies an...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...