Clerodendron colebrookianum Walp., (Fam: Verbenaceae) locally known is "NEFAFU" is widely used for curing various diseases. Here some pharmacological properties of this plant were studied using rat & mice of either sex. Methanol extract (MLE) of various concentrations (50, 100, 200 mg/kg of body wt) were tested on animals. Carrageenin induced rat paw oedema model with three hours for oedema for...

Primary dysmenorrhea (PD) is a common gynecological disorder. Hitherto, animal models which recapitulate clinical features of PD have not been fully established. We aimed to examine whether a pain model in mice could mimic the clinic features of PD. After pretreated with estradiol benzoate (1 mg/kg/day) intraperitoneally (i.p.) for 3 consecutive days, non-pregnant female Imprinting Control Regi...

s | 31 1 Eskisehir Osmangazi University Medical School, Department of Pharmacology 2 Eskisehir Osmangazi University Medical School, Department of Anaesthesiology and Reanimation Abstract Objective: Curcumin, an active substance of the plant Curcuma longa, was reported to exhibit antiinflammatory, antioxidant, anticancer, antimicrobial ve antilipidemic features. The aim of this study is to inves...

Amaranthus tricolor Linn. (FamilyAmaranthaceae) popularly known as Joseph’s coat in English. The plant has been used as hepatoprotective and hypoglycemic in Indian system of traditional medicine. In present study the hydroalcoholic extract of leaves of Amaranthus tricolor L. (HAEAT) 100, 200 and 400 mg/kg body weight was studied for anti-nociceptive and anti-inflammatory activities in various a...

OBJECTIVES Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). MATERIALS AND METHODS Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing in...

Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole). A therapeutic dose of 28 mg/kg was tested for [Cu(fen)2(im)2] and 21 mg/kg was employed for Fenoprofen calcium, administered by oral gavage...

The aim of this study was to investigate the possible analgesic and anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AM(EtOH)). Two models were employed for evaluation of the analgesic effects: acetic acid-induced writhing response and formalin-induced paw licking. The results demonstrated that AM(EtOH) decreased writhing response for both the acetic acid assay ...

Compound trans-4-(p-bromophenyl)-4-(dimethylamino)-1-(2-thiophen-2-yl-ethyl)-cyclohexanol (C8813), structurally unrelated to morphine, is a novel analgesic. The present study examined the antinociception, opioid receptor selectivity and in vitro activity of C8813. The antinociceptive activity was evaluated using mouse hot plate and acetic acid writhing tests. In mouse hot plate test, the antino...

Ethanolic extract of the roots of A. racemosus improved the stress tolerance in chemical writhing test and swimming endurance test at all the doses as compared to stress control group. Restraint stress induced elevation of blood glucose, triglyceride and cholesterol levels were significantly lowered by pretreatment with extract. Moreover, stress induced variations in levels of lipid peroxidatio...

In the present investigation, two novel series of 2-[3-(4-chlorophenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole and 2-[3-(4-ethylphenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole were synthesized and tested for their antiinflammatory, analgesic, ulcerogenic and antibacterial actions. A fair number of compounds were found to have very good antiinflammatory activity in car...