It is well documented that physiological and morphological properties of anchored cells are influenced by fluid shear stress. Common orbital shakers provide a means of simultaneously applying shear stress to cells for tens to hundreds of cases by loading the shaker with multiple dishes. However, the complex flow in orbiting dishes is amenable to analytical solution for resolving shear created b...

The average wall shear stress (WSS) is in 1 Pa range in coronary arteries, while the stretching effect of an implanted coronary stent can generate up to 3 × 105 times higher circumferential stress in the vessel wall. It is widely accepted that WSS plays a critical role in the development of restenosis after coronary stent implantation, but relevant clinical endpoint studies are lack-ing. Fluid ...

Background Different methods have been proposed to estimate Wall Shear Stress (WSS). Morgan and co-workers (J Thorac Cardiovasc Surg and Ann Biomed Eng 1998) used a finite difference scheme to quantify the WSS tensor. However, it is well known that finite-difference methods cannot effectively handle complex geometries, as those found in the cardiovascular system. To account for arbitrary cross-...

In cultured endothelial cells, Ca2+-dependent and -independent activation of nitric oxide (NO) synthesis to agonists and flow/wall shear stress (WSS) has been demonstrated. However, the presence and function of these pathways are less well known in microvessels that can be exposed to a high level of WSS. We hypothesized that the role of changes in endothelial intracellular calcium concentration...

BACKGROUND AND PURPOSE the purpose of this study was to identify significant morphological and hemodynamic parameters that discriminate intracranial aneurysm rupture status using 3-dimensional angiography and computational fluid dynamics. METHODS one hundred nineteen intracranial aneurysms (38 ruptured, 81 unruptured) were analyzed from 3-dimensional angiographic images and computational flui...

Venous injury and subsequent venous stenosis formation are responsible for hemodialysis graft failure. Our hypothesis is that these pathological changes are in part related to changes in wall shear stress (WSS) that results in the activation of matrix regulatory proteins causing subsequent venous stenosis formation. In the present study, we examined the serial changes in WSS, blood flow, and lu...

1 Main Theme of Thesis Web Services (WSs) are modular, self-describing, loosely-coupled, platform and programming language-agnostic software applications that can be advertised , located and used across the Internet. They are viewed as one of the promising technologies that could help business entities to automate their operations on the web on a large scale by automatic discovery and consumpti...

Tolerance and dependence are two main problems that have limited morphine administration. There are several reports on the effect of some medicinal plants on morphine-induced tolerance and dependence. In this study we investigated the effect of Ferula persica (FP) extract on modulation of withdrawal syndrome sign (WSS). For this purpose, male Albino mice (25-30 g, n=30) were used. Morphine was ...

Tolerance and dependence are two main problems that have limited morphine administration. There are several reports on the effect of some medicinal plants on morphine-induced tolerance and dependence. In this study we investigated the effect of Ferula persica (FP) extract on modulation of withdrawal syndrome sign (WSS). For this purpose, male Albino mice (25-30 g, n=30) were used. Morphine was ...