نتایج جستجو برای: xlf
تعداد نتایج: 235 فیلتر نتایج به سال:
We present results of morphological and spectroscopic study of hot gas in some early-type galaxies based on the analysis of high resolution X-ray images acquired from the archive of Chandra space mission. Distribution of the hot gas in target galaxies after eliminating contribution from the discrete sources (LMXBs) displays varied morphologies, ranging from very compact nuclear emission to very...
The ever-expanding observational sample of X-ray binaries (XRBs) makes them excellent laboratories for constraining binary evolution theory. Such constraints can be obtained by studying the effects various physical assumptions on synthetic luminosity functions (XLFs) and comparing to observed XLFs. In this work, we focus high-mass XRBs (HMXBs) study XLF various, poorly-constrained regarding pro...
In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PK(cs) to form the active DNA-dependent protein kinase, DNA-PK. Subsequently, XRCC4, DNA ligase IV, XLF and most likely, other unidentified components participate in the final DSB ligation step...
DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
Cernunnos/XLF is a core protein of the nonhomologous DNA end-joining (NHEJ) pathway that processes the majority of DNA double-strand breaks in mammals. Cernunnos stimulates the final ligation step catalyzed by the complex between DNA ligase IV and Xrcc4 (X4). Here we present the crystal structure of the X4(1-157)-Cernunnos(1-224) complex at 5.5-Å resolution and identify the relative positions o...
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