In Drosophila, the gene Sex-lethal (Sxl) is required for female development. It controls sexual differentiation in the soma, dosage compensation and oogenesis. The continuous production of SXL proteins in XX animals is maintained by autoregulation and depends on virilizer (vir). This gene is required in somatic cells for the female-specific splicing of Sxl primary transcripts and for an unknown...

Profiles of polarity across biological membranes are essential determinants of the cellular permeability barrier and of the stability of transmembrane proteins. High-field electron paramagnetic resonance of systematically spin-labeled lipid chains is used here to determine the polarity profiles of cholesterol-containing phospholipid membranes. The polarity dependence of the g(xx)-tensor element...

Using molecular chromosomal analyses, we discovered night monkey hybrids produced in captivity from matings between a female Aotus azarae boliviensis (2n = 50) and a male Aotus lemurinus griseimembra (2n = 53). The parents produced seven offspring in total, including one male and six females-a pattern consistent with Haldane's rule. Chromosomal studies were conducted on four of the hybrid offsp...

BACKGROUND Previously, investigators suggested that diagnostic substitution from other diagnoses, e.g., mental retardation (MR) and/or cerebral palsy (CP) to pervasive developmental disorder (PDD) is a driving factor behind increases in autism. This study evaluated potential diagnostic substitution among subjects diagnosed with PDD vs. MR or CP by examining birth characteristic overlap. METHO...

Searching PubMed and other citation resources is an essential component of evidencebased practice. The inability to create effective searches can impact the ability of clinicians to incorporate evidence into their decision-making processes. This paper describes four strategies to help clinicians find evidence efficiently through targeted, well-designed literature searches. Int J Evid Based Prac...

A patient with Down's syndrome was found to have 47,XX,+18/47,XX,+21 mosaicism. Chromosome 18 trisomy was found only in 18% of lymphocytes and not in skin fibroblasts. A likely interpretation is double nondisjunction in a single lymphocyte precursor of a trisomy 21 embryo. A brief review of other cases of mitotic multiple nondisjunction and double aneuploid mosiacism is presented.

As is well-known, Axel Thue constructed an infinite word over a 3-letter alphabet that contains no squares, that is, no nonempty subwords of the form xx. In this paper we consider a variation on this problem, where we try to avoid approximate squares, that is, subwords of the form xx where |x| = |x| and x and x are “nearly” identical.

at 25 years of age she had received no hormonal therapy and had experienced no menstrual bleeding. At 6 years of age she had 'Bright's disease' which resolved after several months' stay in hospital. Her general health thereafter was excellent apart from intermittent, mild peripheral oedema. Her physical examination showed a height of 155 cm, a weight of 62 kg, a blood pressure of 130/70, modera...

We report on robust features of the longitudinal conductivity (σ(xx)) of the graphene zero-energy Landau level in the presence of disorder and varying magnetic fields. By mixing an Anderson disorder potential with a low density of sublattice impurities, the transition from metallic to insulating states is theoretically explored as a function of Landau-level splitting, using highly efficient rea...

Received XX Month XXXX; revised XX Month, XXXX; accepted XX Month XXXX; posted XX Month XXXX (Doc. ID XXXXX); published XX Month XXXX Abstract: We present a system, which is based on a new external, polarization-insensitive differential interference contrast (DIC) module, specifically adapted for detecting defects in semiconductor wafers. We obtained defect signal enhancement relative to the s...