We report the discovery, mapping, and characterization of a meiotic drive locus (D) exhibiting nearly 100% nonrandom transmission in hybrids between two species of yellow monkeyflowers, outcrossing Mimulus guttatus and selfing M. nasutus. Only 1% of F(2) hybrids were M. nasutus homozygotes at the marker most tightly linked to D. We used a set of reciprocal backcrosses to distinguish among male-...

BACKGROUND The PAR proteins are part of an ancient and widely conserved machinery for polarizing cells during animal development. Here we use a combination of genetics and live imaging methods in the model organism Caenorhabditis elegans to dissect the cellular mechanisms by which PAR proteins polarize cells. RESULTS We demonstrate two distinct mechanisms by which PAR proteins polarize the C....

cardiac magnetic resonance imaging (cmri) is a well-established noninvasive imaging modality in clinical cardiology. its ability to provide tissue characterization make it well suited for the study of patients with cardiac diseases. we describe a multi-modality imaging evaluation of a 45-year-old man who experienced a near drowning event during swimming. we underline the unique capability of ti...

further to our recently published findings, we have completed the analysis of our second year of prehospital data collection for the same service. we wish to expedite the availability of this data to clinicians, researchers and policy makers in the region. our 2015/2016 out-of-hospital cardiac arrest (ohca) data displayed the following demographic results: 514 ohca resuscitation attempts were a...

background: tramadol is a widely used centrally acting opioid analgesic and due to its ease of access in iran as an over-the- counter drug, reported cases of intoxication are rising. case: a 19-year-old male who was referred to our center, noor hospital, isfahan university of medical sciences, isfahan, iran, because of confusion, ataxia, agitation and an episode of seizure, followed by intentio...

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase, whereas PAR-3 is a PDZ-domain-containing scaffold protein. Work over the past decade has shown that they are part of an evolutionarily conserved PAR-aPKC system involved in cell polarity in various biological contexts. Rece...

introduction: pronuclear size, morphology and orientation are known to affect embryo quality and implantation. the present study was aimed at evaluation of the possible relationship between protamine deficiency with pronuclear morphology and also cleavage and embryo quality. material and methods: semen sample of 160 candidate icsi and ivf couples were analyzed for sperm concentration, and motil...

background: multiple factors have been suggested for prediction of pregnancy in intracytoplasmic sperm injection (icsi) cycles such as the number of injected oocytes, fertilization rate, embryo morphology and quality of transferred embryos. predictive value of these factors is important in icsi outcome. objectives: to evaluate the role of embryo morphology for prediction of pregnancy in icsi cy...