Optically pure â,â-dimethylated amino acid building blocks with functionalized side chains have been prepared from D-aspartic acid. The dimethylation was accomplished by regioselective dialkylation of 9-phenylfluorenyl (PhFl)-protected aspartate diesters. The bulk of the PhFl protecting group also allowed for a variety of functional group manipulations to be carried out on the side chain withou...

ti,2f3= 99.0 ± 44.5 mm, t112y = 1213 ± 493 mm, V@ (Va) 4.81 ±2.l2lihens, V@= 58.2 ±50.Slihens,V7 = 598 ±294 liters. Vincnishine, studied only for hhe finsh 4 hn, behaved like a Iwo-compartment system, wihh values of t,,2 a 3.37 ±0.72 min,t,,2 /3 = 155 ±18 mm, v@= 4.53 ±0.49 liters, and V@ = 57.3 ± 21.1 liters. Urine excretiondaha demonstrahed that most drug elimination occurred wihhin ...

N. Marõ  n, Dpto. de Dida  ctica de la Matematica y de las Ciencias Experimentales, Facultad de Ciencias de la Educacio  n, Universidad de Almerõ  a, Spain A. Benarroch, Dpto. de Dida  ctica de las Ciencias Experimentales, Escuela de Magisterio de Melilla, Universidad de Granada, Spain E. Jime  nez Go  mez, Dpto. de Dida  ctica de las Ciencias Experimentales, Facultad de Educacio  n, U...

to 0.294)Affective disorders0.0910.040(6)(—0.325 to 0.421)Adjustment disorders0.5230.298(7)(—0.067 to 0.766)Anxiety disorders0.5630.369(7)(—0.069 to 0.577)Inappropriate mental0.4040.304adjustment (7)(—0.3 12 to 0.45 1)Somatoform disorders0.6030.281(6)(0.239 to 0.556)Personality disorders0.5090.3 17(7)(—0.028 to 0.523)Factor 1: affective0.6930.342(14)(—0.273 to 0.613)Factor 2: somato...

classes in N(p,q). We show that X(p,q) with the quotient topology is homeomorphic to the compact, connected quotient space G(p, so(q,Â)) / SL(q,Â), where SL(q,Â) acts on so(q,Â) and the associated Grassmann manifold G(p, so(q,Â)) by g(Z) = gZgt for Z ∈ so(q,Â) and g ∈ SL(q,Â). It follows immediately that X(p,q) is homeomorphic to X(D−p,q), where D = dim so(q,Â) = (1/2)q(q−1) (duality). For each...

We have examined the responses of energy and protein metabolism to nutrient intake in nine patients with lung carcinoma, of whom none »ere cachexie and only one had distant métastases,compared with nine control patients for elective aneurism surgery, who were comparable in terms of age, body mass index, and smoking habits. Whole-body protein turnover and leucine oxidation were assessed by pri...

We have examined the responses of energy and protein metabolism to nutrient intake in nine patients with lung carcinoma, of whom none »ere cachexie and only one had distant métastases,compared with nine control patients for elective aneurism surgery, who were comparable in terms of age, body mass index, and smoking habits. Whole-body protein turnover and leucine oxidation were assessed by pri...

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The limited angular resolution of γ–ray telescopes prevents the straight identification of the majority of the sources detected so far. This is particularly true for the low latitude, probably galactic ones, only 10 % of which has been identified. Most of the counterparts are Isolated Neutron Stars, both radio–loud and radio–quiet, characterised by an extremely high value of fX /fopt. The best ...