Pancreatic cancer is an aggressive malignancy that is unresponsive to conventional radiation and chemotherapy. Therefore, development of novel immune therapeutic strategies is urgently needed. L-4F, an Apolipoprotein A-I (ApoA-I) mimetic peptide, is engineered to mimic the anti-inflammatory and anti-oxidative functionalities of ApoA-I. In this work, H7 cells were orthotopically implanted in C57...

The site and mechanism of action of the apoA-I mimetic peptide 4F are incompletely understood. Transintestinal cholesterol efflux (TICE) is a process involved in the clearance of excess cholesterol from the body. While TICE is responsible for at least 30% of the clearance of neutral sterols from the circulation into the intestinal lumen, few pharmacological agents have been identified that modu...

In this paper, we prove the generalized Hyers–Ulam stability of the following additive-quadratic-cubic-quartic functional equation f(x + 2y) + f(x− 2y) = 4f(x + y) + 4f(x− y)− 6f(x) + f(2y) + f(−2y)− 4f(y)− 4f(−y) in non-Archimedean Banach spaces.

BACKGROUND Patients experiencing major bleeding while taking vitamin K antagonists require rapid vitamin K antagonist reversal. We performed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4F-PCC) with plasma for urgent vitamin K antagonist reversal. METHODS AND RESULTS In this phase IIIb, multicenter, open-label, noninferiority trial, nonsurgica...

Metal (4f)-ligand (Cl 3p) bonding in LnCl(6)(3-) (Ln = Ce to Yb) complexes has been studied on the basis of 4f-->4f and Cl,3p-->4f charge-transfer spectra and on the analysis of these spectra within the valence bond configuration interaction model to show that mixing of Cl 3p into the Ln 4f ligand field orbitals does not exceed 1%. Contrary to this, Kohn-Sham formalism of density functional the...

Tuxworth, William J., Jr., Hisayasu Wada, Yuji Ishibashi, and Paul J. McDermott. Role of load in regulating eIF-4F complex formation in adult feline cardiocytes. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1273–H1282, 1999.— This study examined whether cardiocyte load increases eIF-4F complex formation. To increase load in vitro, adult feline cardiocytes were electrically stimulated to cont...

Lanthanides in compounds can adopt the tetravalent [Xe]4f n−1 (like Ce4+, Pr4+, Tb4+), the trivalent [Xe]4f n (all lanthanides), or the divalent [Xe]4f n+1 configuration (like Eu2+, Yb2+, Sm2+, Tm2+). The 4f -electron binding energy depends on the charge Q of the lanthanide ion and its chemical environment A. Experimental data on three environments (i.e., the bare lanthanide ions where A = vacu...

The hybridization between localized 4f electrons and itinerant electrons in rare-earth-based materials gives rise to their exotic properties like valence fluctuations, Kondo behaviour, heavy-fermions, or unconventional superconductivity. Here we present an angle-resolved photoemission spectroscopy (ARPES) study of the Kondo lattice antiferromagnet CeRh2Si2, where the surface and bulk Ce-4f spec...

BACKGROUND Apolipoprotein A1 mimetic peptide, synthesized from D-amino acid (D-4F), enhances the ability of HDL to protect LDL against oxidation in atherosclerotic animals. METHODS AND RESULTS We investigated the mechanisms by which D-4F provides antioxidant effects in a diabetic model. Sprague-Dawley rats developed diabetes with administration of streptozotocin (STZ). We examined the effects...