background despite significant advances in the treatment of chronic hepatitis c in the past decades, factors which can affect response rates to combination therapy; peginterferon and ribavirin, are still under study and reaching sustained virological response (svr) is affected by several different factors. objectives to investigate predictor factors contributing to svr in iranian patients. pati...

background: hepatitis c virus (hcv) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. in this study we aimed to evaluate the effects of pegylated interferon alfa-2a (peg-ifn a-2a) in reducing serum alt and eradicating serum hepatitis c virus (hcv) rna in hcv infected polytransfused thalassemic patients. materials and methods: a cohort of 51 hcv-...

The aim of this research note is to prove the following new transformation formula begin{equation*} (1-x)^{-2a},_{3}F_{2}left[begin{array}{ccccc} a, & a+frac{1}{2}, & d+1 & & \ & & & ; & -frac{4x}{(1-x)^{2}} \ & c+1, & d & & end{array}right] \ =,_{4}F_{3}left[begin{array}{cccccc} 2a, & 2a-c, & a-A+1, & a+A+1 & & \ & & & & ; & -x \ & c+1, & a-A, & a+A & & end{array} right], end{equation*} wher...

background chronic hepatitis b is one of the most common causes of cirrhosis and hepatocellular toxicity in many countries, including iran. cytotoxic t lymphocyte (ctl) and natural killer (nk) cells are the two of main cell populations considered as cytotoxic cells. one of the distinct pathways ctl and nk cells exert cytotoxicity is perforin/granzyme. after the cytotoxic cell/target cell juncti...

BACKGROUND: Canine parvovirus (CPV) infection is one ofthe most common causes of infectious gastroenteritis in dogs andis a highly contagious, often fatal disease. The original virus(CPV type 2) has had some mutations since its emergence andnew variants (CPV-2a, 2b and 2c) have been reported from manycountries all around the world. Early diagnosis and treatment canprofoundly affect the disease ...

  Parechoviruses form one of the nine genera in the picornaviridae family, and include two human pathogens: Human parechovirus type1 and 2 (Hpev1 and Hpev2). The genome of picornaviruses encodes a single polyprotein, which undergoes a cleavage cascade performed by virus encoded proteases to give the final virus proteins. The primary cleavage occurs by 2A protein and this step is critical for vi...

Reactions of 1 ,Zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated. Benzyne acts as an oxidizing agent to convert dihydropyridine (la) and (2a) to the corresponding pyridine (4) or adds as a dienophile to (lb-c).