Rational engineering of filamentous fungi for improved cellulase production is hampered by our incomplete knowledge of transcriptional regulatory networks. We therefore used the model filamentous fungus Neurospora crassa to search for uncharacterized transcription factors associated with cellulose deconstruction. A screen of a N. crassa transcription factor deletion collection identified two un...

Calcitonin gene-related peptide (CGRP) mediates neurogenic inflammation and modulates intestinal motility. The CGRP receptor is a heterodimer of calcitonin receptorlike receptor (CLR) and receptor-associated modifying protein 1 (RAMP1). We used RNA interference (RNAi) to elucidate the specific role of CLR in colonic motility and inflammation. Intramural injection of double-stranded RNA (dsRNA) ...

Calcitonin gene-related peptide (CGRP) mediates neurogenic inflammation and modulates intestinal motility. The CGRP receptor is a heterodimer of calcitonin receptor-like receptor (CLR) and receptor-associated modifying protein 1. We used RNA interference to elucidate the specific role of CLR in colonic motility and inflammation. Intramural injection of double-stranded RNA (dsRNA) against CLR (d...

This simulation-based report compares the performance of five methods of association analysis in the presence of linkage using extended sibships: the Family-Based Association Test (FBAT), Empirical Variance FBAT (EV-FBAT), Conditional Logistic Regression (CLR), Robust CLR (R-CLR) and Sibship Disequilibrium Test (SDT). The two tests accounting for residual familial correlation (EV-FBAT and R-CLR...

The implementation of statically typed programming languages on the .NET CLR is by now well understood [1]. However, the situation with dynamic languages is not so clear. Typically such languages have objects that are dynamically typed, while the CLR is statically typed at the instruction code level. Nevertheless there is a growing body of evidence suggesting that the CLR can be a suitable targ...

“Clear” (CLR) speech is a speaking style that speakers adopt to be understood correctly in a difficult communication environment. Studies have shown that CLR speech, as opposed to “conversational” (CNV) speech, has significantly higher intelligibility in various conditions. While many differences in acoustic features have been identified, it is not known which individual feature or combinations...

The emergence of antibiotic resistance in mycobacteria involves the selection of mutant variants within a susceptible bacterial population. However, it is unclear whether antimycobacterial drugs act just as selective agents or can influence the rate of appearance of resistant mutants. The present study was initiated to address this issue by monitoring the effects of antimicrobial agents on the ...

The recommended treatments for Mycobacterium avium complex (MAC) infectious disease are combination regimens of clarithromycin (CLR) or azithromycin with ethambutol and rifamycin. However, these chemotherapy regimens are sometimes unsuccessful. Recently developed antimicrobial agents, such as newer fluoroquinolones (FQs) containing C-8 methoxy quinolone (moxifloxacin [MXF] and gatifloxacin [GAT...

Dietary supplementation with conventional linted cottonseed hulls (LCSH) is a common practice in livestock production all over the world. However, supplementation with mechanically delinted cottonseed hulls (DCSH) and cottonseed linter residue (CLR) is uncommon. Cottonseed by-products, including LCSH, DCSH and CLR, were assessed by chemical analysis, an in situ nylon bag technique, an in vitro ...

The .NET Common Language Runtime (CLR) offers a new opportunity to experiment with multi-language interoperation, and provides a relatively rare chance to explore deep interoperation of a wide range of programming language paradigms. This article describes how the logic/functional programming language Mercury is compiled to the CLR. We describe the problems we have encountered with generating c...