metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the  liver  does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...

Model-free learning for multi-agent stochastic games is an active area of research. Existing reinforcement algorithms, however, are often restricted to zero-sum games, and applicable only in small state-action spaces or other simplified settings. Here, we develop a new data efficient Deep-Q-learning methodology model-free Nash equilibria general-sum games. The algorithm uses local linear-quadra...

Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...

background nafld/nash is a manifestation of metabolic syndrome and is associated with obesity/overweight. not all obese/overweight individuals develop nash. gastro-esophageal reflux disease (gerd) is considered a gastrointestinal manifestation of the metabolic syndrome and is associated with obesity/overweight. again not all obese/overweight individuals develop gerd. recent data show associatio...

objective(s):non-alcoholic steatohepatitis (nash), is an important component of non-alcoholic fatty liver disease (nafld) spectrum, which progresses to the end stage liver disease, if not diagnosed and treated properly. the disproportionate production of pro- and anti-inflammatory adipokines secreted from fat contributes to the pathogenesis of nash. in this study, the comparative effect of piog...