BACKGROUND Acute mountain sickness (AMS) commonly occurs when unacclimatized individuals ascend to altitudes above 2000 m. Acetazolamide and Ginkgo biloba have both been recommended for AMS prophylaxis; however, there is conflicting evidence regarding the efficacy of Ginkgo biloba use. We performed a randomized, placebo-controlled trial of acetazolamide vs Ginkgo biloba for AMS prophylaxis. M...

QUESTION Does Ginkgo biloba reduce incident dementia and Alzheimer disease in elderly people with normal cognition or mild cognitive impairment? METHODS Design: randomised placebo controlled trial (Ginkgo Evaluation of Memory [GEM] study). ClinicalTrials.gov NCT00010803. Allocation: unclear allocation concealment.* Blinding: blinded (patients, clinicians, and outcome assessors).* Follow-up peri...

Ginkgo biloba leaf extract has been shown to increase the incidence in liver tumors in mice in a 2-year bioassay conducted by the National Toxicology Program. In this study, the DNA damaging effects of Ginkgo biloba leaf extract and many of its constituents were evaluated in human hepatic HepG2 cells and the underlying mechanism was determined. A molecular docking study revealed that quercetin,...

Ginkgo biloba has been used in traditional Chinese medicine for about 5000 years. A standardized preparation, EGb 761 has been recently prepared. The pharmacologically active constituents, flavonol glycosides and the terpene lactones are standardized. The terpene lactones comprise of ginkgolides A, B, C and bilobalides. The extract scavenges excess free radicals and pretreatment with EGb 761 re...

The effects of process parameters on the extraction of Ginkgo biloba L. leaves with supercritical carbon dioxide were investigated. The investigated parameters include particle size (mean particle diameter 0.19, 0.467 and 1.009 mm), solvent flow rate (1.58×10, 3.22×10 and 4.16×10 kg CO2/min) and pressure (100–300 bar), which were obtained by the response surface methodology (RSM) under the foll...

Ginkgo biloba, the ginkgo tree, is the oldest living tree, with a long history of use in traditional Chinese medicine. In recent years, the leaf extracts have been widely sold as phytomedicine in Europe and as a dietary supplement worldwide. Effects of Ginkgo biloba extracts have been postulated to include improvement of memory, increased blood circulation, as well as beneficial effects to suff...

The Ginkgo biloba special extract EGb 761 seems to produce neuroprotective effects in neurodegenerative diseases of multifactorial origin. There is still debate about the efficacy of Ginkgo biloba special extract EGb 761 compared with second-generation cholinesterase inhibitors in the treatment of mild to moderate Alzheimer's dementia. Our aim is to assess the efficacy of the Ginkgo biloba spec...

OBJECTIVES To assess the efficacy of the Ginkgo biloba in patients with dementia of the Alzheimer type in slowing down the disease's degenerative progression and the patients' cognitive impairment compared with rivastigmine. METHODS Total 56 patients aged 50-75 years, suffering from dementia, were allocated into one of the two treatments: group 1) Ginkgo biloba (120 mg daily dose); group 2) r...

Soil carbon (C) in three Ginkgo (Ginkgo biloba L.) agroforestry systems, afforestation (Ginkgo alone; G), and an agricultural cropping system were compared over a five-year period. The agroforestry systems were Ginkgo + Wheat (Triticum aestivum L.) + Peanut (Arachis hypogaea L.; GWP); Ginkgo + Mulberry (Morus alba L.; GM); and Ginkgo + Rapa (Brassica napus L.) + Peanut (GRP). The agricultural s...