Increased -synuclein ( syn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson’s disease (PD), and lowering syn is under intensive investigation as a therapeutic strategy for PD. Increased syn levels disrupt mitochondria and impair respiration, while reduced syn protects against mitochondrial toxins, suggesting that interactions between syn and mitochondria influe...

Post-mortem analyses of brains from patients with Parkinson disease who received fetal mesencephalic transplants show that α-synuclein-containing (α-syn-containing) Lewy bodies gradually appear in grafted neurons. Here, we explored whether intercellular transfer of α-syn from host to graft, followed by seeding of α-syn aggregation in recipient neurons, can contribute to this phenomenon. We asse...

This paper presents a simple and robust mechanism called SYN-dog to sniff SYN flooding sources. We install SYN-dog as a software agent at leaf routers that connect stub networks to the Internet. The statelessness and low computation overhead of SYN-dog make itself immune to any flooding attacks. The core mechanism of SYN-dog is based on the protocol behavior of TCP SYN—SYN/ACK pairs, and is an ...

Extant and fossil genera and species in the Libytheinae (Nymphalidae) are revised and reviewed. The Libytheinae includes two genera: Libythea Fabricius and Libytheana Michener. Fifteen species and an additional 24 subspecies are recognized and 41 names are synonymized. Species recognized are: Libythea celtis (Laicharting), L. collenettei Riley, L. cinyras Trimen revised status, L. geoffroyi God...

The following synonymies are proposed based on examination of primary types (lectotypes are designated for all taxa except those marked with a '*'): Lemidia spinnipennis Lea, 1907 syn. n. and Lemidia bicolor Schenkling, 1906 syn. n. = Lemidia biaculeata (Westwood); Lemidia mastersi Lea, 1907 syn. n. = Lemidia circumcincta Schenkling, 1906; Lemidia albonotata Pic, 1941 syn. n. = Lemidia laticeps...

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not trigger the formation of fibrillar LB-like inclusions in mice. We hypothesized that interactions betw...

A pre-phylogenetic revision of the family Phalacridae at the genus level is presented. Twenty-eight new generic synonymies are established as follows: Acylomus Sharp 1888 (=Liophalacrus Sharp 1888, syn. nov.; Ganyrus Guillebeau 1894, syn. nov.; Podocesus Guillebeau 1894, syn. nov.; Tinodemus Guillebeau 1894, syn. nov.; Ledorus Guillebeau 1895, syn. nov.; Astenulus Guillebeau 1896, syn. nov.; Af...

We present ANEMONA: a language for distributed network management programming. The compilation of an ANEMONA program generates code for configuring DisMan MIB’s thus automating a complex task that is prone to errors if done manually. The language allows the definition of expressions of managed objects that are monitored, as well as triggers that when fired may indicate the occurrence of associa...

A taxonomic revision of the genus Megalostomis Chevrolat, 1836 (Coleoptera: Chrysomelidae: Cryptocephalinae: Clytrini: Megalostomina) is provided, including new data on geographic ranges. Two new species and 34 new synonymies are proposed within the genus Megalostomis, leaving 42 valid species in the genus. A checklist of the species of Megalostomis is provided, with information on host plants,...