Certain genomic loci, termed hot spots, are predisposed to undergo genetic recombination during meiosis at higher levels relative to the rest of the genome. The factors that specify hot-spot potential are not well understood. The M26 hot spot of Schizosaccharomyces pombe is dependent on certain trans activators and a specific nucleotide sequence, which can function as a hot spot in a position- ...

The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate d e 6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G + T nucleotide change, that M26 stimulated recombination within ade6 but not at other distant loci, and that M26 stimulated meiotic but not mitotic recombination. In addition, M26 stimulated recombination wit...

The heptamer sequence ATGACGT is essential for activity of the M26 meiotic recombination hotspot in the ade6 gene of Schizosaccharomyces pombe. Hotspot activity is associated with binding of the heterodimeric transcription factor Atf1.Pcr1 to M26. We have found that the sequences (C/T/G) TGACGT also bound Atf1.Pcr1 and acted as meiotic hotspots, but unlike M26 they must be followed by A or C fo...

Two different strains of Rhizopus sp. i.e. R. oligosporus -M30 and R. arrhizus -M26 were employed for the production of acid protease using different agro-residues such as rice husk, rice bran, wheat bran, defatted soybean meal and sunflower meal as a sole carbon source. R. oligosporus -M30 gave maximum enzyme level with soybean meal (15.6 U/gds) while R. arrhizus -M26 with sunflower meal (13.6...

2. DOMILL has issued five previous statements relating to the medical implications of the Taser M26 and Taser X26 less-lethal systems. 4 The Taser X26 conducted energy device was introduced into UK policing in 2005 as a replacement for the Taser M26. Recent data from the Home Office Centre for Applied Science and Technology (CAST) indicate that the Taser X26 is the device primarily in use by th...

Chromatin remodeling plays crucial roles in the regulation of gene expression and recombination. Transcription of the fission yeast fbp1(+) gene and recombination at the meiotic recombination hotspot ade6-M26 (M26) are both regulated by cAMP responsive element (CRE)-like sequences and the CREB/ATF-type transcription factor Atf1*Pcr1. The Tup11 and Tup12 proteins, the fission yeast counterparts ...