In a previous study of the potential mutagenic action of isoflurane using the sister chromatid exchange (SCE) test in lymphocytes of surgical patients, it appeared that SCE increased in a group of 11 cigarette smokers, there being no effect in patients who were non-smokers. In the present study, 63 cigarette smokers were examined by the SCE test before and after minor orthopaedic operations und...

Borderline personality disorder (BPD) is associated with a proneness to unpleasant self-conscious emotions (SCE). Given that BPD is also associated with heightened rates of SCE-eliciting events (including unwanted sexual experiences), research examining the factors influencing SCE in response to these events is needed. This study examined associations between BPD pathology and SCE in response t...

The objective of this study was to determine if cytogenetic markers can be used as indicators of prior exposure to arsenic compounds. Baseline sister chromatid exchange (SCE) and mitomycin C-induced (MMC) SCE were measured in four study populations recruited from a blackfoot (BF) disease endemic area, including 22 patients with cancer (CA) only, 8 patients with both BF disease and CA (BF+CA), 1...

IMPORTANCE As medical school curricula become progressively integrated, a need exists to optimize education related to the skin cancer examination (SCE) for melanoma, a relevant competency gap that influences secondary prevention efforts. OBJECTIVES To identify curricular factors associated with medical students' confidence, intent, and performance regarding the SCE. DESIGN, SETTING, AND PA...

Cyclosporine A (CsA) is a powerful immunosuppressive drug. However, nephrotoxicity resulting from its long-term usage has hampered its prolonged therapeutic usage. Schisandra chinensis extracts (SCE) have previously been used in traditional Chinese medicine and more recently coadministered with Western medicine for the treatment of CsA-induced side effects in the People's Republic of China. Thi...

The potential mutagenicity of isoflurane was investigated by the sister chromatid exchange (SCE) test using peripheral blood lymphocytes from patients before and after anaesthesia. Thirty patients, aged 18-59 yr (median 29.5 yr), were anaesthetized for minor orthopaedic operations with isoflurane and nitrous oxide in oxygen for 37-90 min (median 64 min). Venous blood samples were drawn before t...

OBJECTIVE To determine physician preparation for performing the skin cancer examination (SCE). DESIGN We evaluated medical students' observation, training, and practice of the SCE; hours spent in a dermatology clinic; and self-reported skill level for the SCE by a self-administered survey. PARTICIPANTS Graduating students at 7 US medical schools during the 2002-2003 academic year. MAIN OU...

one of the most important and valuable goal of software development life cycle is software cost estimation or sce. during the recent years, sce has attracted the attention of researchers due to huge amount of software project requests. there have been proposed so many models using heuristic and meta-heuristic algorithms to do machine learning process for sce. cocomo81 is one of the most popular...

Ethylene oxide (EtO) ¡sa potent DNA-alkylating agent which has been shown to induce sister chromatid exchanges (SCE) in the peripheral blood lymphocytes of exposed workers. To study further the persistence of EtO-induced SCE, we have examined lymphocytes from a group of cynomolgus monkeys exposed to EtO in control, 50-ppm, and 100-ppm concentrations for 7 h/day, 5 days/week over the years 1979...

Ethylene oxide (EtO) is a potent DNA-alkylating agent which has been shown to induce sister chromatid exchanges (SCE) in the peripheral blood lymphocytes of exposed workers. To study further the persistence of EtO-induced SCE, we have examined lymphocytes from a group of cynomolgus monkeys exposed to EtO in control, 50-ppm, and 100-ppm concentrations for 7 h/day, 5 days/week over the years 1979...